Deferasirox induced liver injury in haemochromatosis.
Summary of "Deferasirox induced liver injury in haemochromatosis."
Durg-induced liver injury is a common side-effect of many medicines. It is particularly problem when the original condition under treatment is already causing liver demage. This report describes the hepatotoxicity induced by Deferasirox in a patient with haemochromatosis with a discussion of possible pathogenetic mechanisum.
Affiliation
Department of Gastroenterology and Hepatology, University of Louisville, KY, USA.
Journal Details
This article was published in the following journal.
Name: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
ISSN: 1022-386X
Pages: 551-3
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20688025
- DOI: http://dx.doi.org/04.2010/JCPSP.551553
Medical and Biotech [MESH] Definitions
Drug-induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Drug-induced Liver Injury, Chronic
Liver disease lasting six months or more, caused by an adverse drug effect. The adverse effect may result from a direct toxic effect of a drug or metabolite, or an idiosyncratic response to a drug or metabolite.
Liver Cirrhosis, Experimental
Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.
Liver Neoplasms, Experimental
Experimentally induced tumors of the LIVER.
Liver Failure, Acute
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
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