Catalytic Asymmetric Claisen Rearrangement of Unactivated Allyl Vinyl Ethers.

06:00 EDT 7th August 2010 | BioPortfolio

Summary of "Catalytic Asymmetric Claisen Rearrangement of Unactivated Allyl Vinyl Ethers."

Nearly a century after their original discovery, catalyzed enantioselective variants of the venerable Claisen rearrangement remain relatively rare. We have discovered a cooperative transition metal-Lewis acid cocatalyst system that affects highly enantio- and diastereoselective examples of archetypical Claisen rearrangements. The catalyzed rearrangements proceed using an easily prepared enantioenriched transition metal catalyst and a commercially available Lewis acid cocatalyst at ambient temperature in common solvents.


Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.

Journal Details

This article was published in the following journal.

Name: Journal of the American Chemical Society
ISSN: 1520-5126


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Medical and Biotech [MESH] Definitions

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