Introduction: Airway hyperresponsiveness in asthma: its measurement and clinical significance.
Summary of "Introduction: Airway hyperresponsiveness in asthma: its measurement and clinical significance."
This supplement to CHEST, titled "Airway Hyperresponsiveness in Asthma: Its Measurement and Clinical Significance," resulted from a symposium that brought together experts from Canada, the United States, and Australia to discuss the progress in the understanding of measurements of airway hyperresponsiveness. There was an additional focus on the indirect measurement of airway inflammation and its interaction with airway hyperresponsiveness, as well as the role of measuring airway inflammation in the management of asthma.
Affiliation
Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Department of Medicine, McMaster University, Hamilton, ON, Canada. obyrnep@mcmaster.ca
Journal Details
This article was published in the following journal.
Name: Chest
ISSN: 1931-3543
Pages: 1S-3S
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20668011
- DOI: http://dx.doi.org/10.1378/chest.10-0091
Medical and Biotech [MESH] Definitions
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Asthma, Exercise-induced
Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).
Airway Remodeling
The structural changes in the number, mass, size and/or composition of the airway tissues.
Airway Management
Evaluation, planning, and use of a range of procedures and airway devices for the maintenance or restoration of a patient's ventilation.
Magnetoencephalography
The measurement of magnetic fields over the head generated by electric currents in the brain. As in any electrical conductor, electric fields in the brain are accompanied by orthogonal magnetic fields. The measurement of these fields provides information about the localization of brain activity which is complementary to that provided by ELECTROENCEPHALOGRAPHY. Magnetoencephalography may be used alone or together with electroencephalography, for measurement of spontaneous or evoked activity, and for research or clinical purposes.
PubMed Articles
Airway hyperresponsiveness (AHR) is a clinical feature of asthma and is often in proportion to the underlying severity of the disease. To understand AHR and the mechanisms that contribute to these pro...
Airway inflammation is fundamental to the cause and persistence of asthma and other airway conditions. It contributes to symptoms, variable airflow limitation, airway hyperresponsiveness, and the stru...
The two key pathophysiologic features of asthma are bronchial hyperresponsiveness (BHR) and airway inflammation. Symptoms and lung function are the most accessible clinical markers for the diagnosis o...
Conclusion: Airway hyperresponsiveness in asthma: its measurement and clinical significance.
Biology of the Interleukin-9 Pathway and its Therapeutic Potential for the Treatment of Asthma.
Asthma is a complex disease characterized by variable airflow limitation, hyperresponsiveness, and airways inflammation. Despite valuable therapeutic advances to control asthma symptoms in the last de...
Clinical Trials
Early Antiinflammatory Treatment of Asthma
- The inflammatory process that leads to the development of asthma may be present before the onset of asthma symptoms and cause a certain degree of airway hyperresponsiveness. W...
Airway Inflammation in Swimmers
Studies have shown that the prevalence of respiratory symptoms, airway hyperresponsiveness (AHR) and asthma is high and increasing in elite athletes. The inflammation seen in the airways o...
Role of Airway Hyperresponsiveness on Performance in Elite Swimmers.
The prevalence of airway hyperresponsiveness (AHR) is very high in elite swimmers, reaching 80% in certain studies. Repeated Chlorine-derivatives exposure may be a major causative factor f...
A Study to Assess the Efficacy, Safety,and Tolerability of CAT-354
To investigate the effects of CAT-354 on airway hyperresponsiveness (AHR) in uncontrolled asthma.
Ciclesonide for the Treatment of Airway Hyperresponsiveness (BY9010/CH-101)
The study objective is to investigate in a placebo-controlled, double-blind manner the effect of inhaled corticosteroid (ciclesonide) on airway hyperresponsiveness measured as having PD15...
