Introduction: Airway hyperresponsiveness in asthma: its measurement and clinical significance.
Summary of "Introduction: Airway hyperresponsiveness in asthma: its measurement and clinical significance."
This supplement to CHEST, titled "Airway Hyperresponsiveness in Asthma: Its Measurement and Clinical Significance," resulted from a symposium that brought together experts from Canada, the United States, and Australia to discuss the progress in the understanding of measurements of airway hyperresponsiveness. There was an additional focus on the indirect measurement of airway inflammation and its interaction with airway hyperresponsiveness, as well as the role of measuring airway inflammation in the management of asthma.
Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Department of Medicine, McMaster University, Hamilton, ON, Canada. email@example.com
This article was published in the following journal.
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20668011
- DOI: http://dx.doi.org/10.1378/chest.10-0091
Medical and Biotech [MESH] Definitions
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).
The structural changes in the number, mass, size and/or composition of the airway tissues.
Evaluation, planning, and use of a range of procedures and airway devices for the maintenance or restoration of a patient's ventilation.
The measurement of magnetic fields over the head generated by electric currents in the brain. As in any electrical conductor, electric fields in the brain are accompanied by orthogonal magnetic fields. The measurement of these fields provides information about the localization of brain activity which is complementary to that provided by ELECTROENCEPHALOGRAPHY. Magnetoencephalography may be used alone or together with electroencephalography, for measurement of spontaneous or evoked activity, and for research or clinical purposes.
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The study objective is to investigate in a placebo-controlled, double-blind manner the effect of inhaled corticosteroid (ciclesonide) on airway hyperresponsiveness measured as having PD15...