Penetration of linezolid into rabbit intervertebral discs and surrounding tissues.
Summary of "Penetration of linezolid into rabbit intervertebral discs and surrounding tissues."
Linezolid belongs to a new class of synthetic antimicrobial agent that is effective for a variety of methicillin-resistant Staphylococcus aureus (MRSA) infections including bone and joint MRSA infections, but the effectiveness of linezolid for the treatment of MRSA spine infection remains controversial. In this study, we investigated the diffusion of linezolid or vancomycin into normal rabbit spinal tissues to determine the adequacy of linezolid for the treatment of spinal infection. The penetration efficacy of linezolid into the annulus fibrosus, nucleus pulposus, and vertebral bone (10, 8, and 10%, respectively) was lower than that of vancomycin (27, 11, and 14%, respectively). The penetration efficacy of linezolid into the bone marrow and iliopsoas muscle (88 and 84%, respectively), however, was higher than that of vancomycin (67 and 9%, respectively). These results suggest that linezolid is inadequate for the treatment of spine infection limited to the intervertebral disc, but may be effective for the treatment of infection extending into the muscle and bone marrow, such as in vertebral osteomyelitis, iliopsoas abscess, and postsurgical infection.
Affiliation
Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Kita-15 Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.
Journal Details
This article was published in the following journal.
Name: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the Euro
ISSN: 1432-0932
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20694846
- DOI: http://dx.doi.org/10.1007/s00586-010-1548-x
Medical and Biotech [MESH] Definitions
Intervertebral Disk Displacement
An intervertebral disk in which the nucleus pulposus has protruded through surrounding fibrocartilage. This occurs most frequently in the lower lumbar region.
Spondylosis
A degenerative spinal disease that can involve any part of the VERTEBRA, the INTERVERTEBRAL DISK, and the surrounding soft tissue.
Intervertebral Disk Degeneration
Degenerative changes in the INTERVERTEBRAL DISK due to aging or structural damage, especially to the vertebral end-plates.
Intervertebral Disk Chemolysis
The dissolving of the nucleus pulposus, the semi-gelatinous tissue of a displaced INTERVERTEBRAL DISK. It is usually achieved by the direct injection of a proteolytic enzyme, especially CHYMOPAPAIN, into the herniated disk.
Perinephritis
Inflammation of the connective and adipose tissues surrounding the KIDNEY.
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