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Statin-associated necrotizing autoimmune myopathy.

09:42 EDT 24th April 2014 | BioPortfolio

Summary of "Statin-associated necrotizing autoimmune myopathy."

Necrotizing autoimmune myopathy (NAM) is a severe adverse effect of statins. We report a 66-year-old Caucasian female who had progressive proximal muscle weakness after treatment with statins. Results of a muscle biopsy showed necrotizing myopathy with minimal inflammatory cell infiltrate and increased major histocompatibility class I antigen expression in muscle fibers. The clinical and laboratory parameters improved significantly with immunosuppressive treatment. Although it is a rare event, statin-induced NAM should be included as a differential diagnosis of myopathies.

Affiliation

Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455-3º andar, sala 3150, São Paulo, CEP 01246-903, Brazil.

Journal Details

This article was published in the following journal.

Name: Modern rheumatology / the Japan Rheumatism Association
ISSN: 1439-7609
Pages:

Links

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