Nanosuspension: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to Amphotericin-B.
Summary of "Nanosuspension: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to Amphotericin-B."
Present limitations in the management of ophthalmic fungal infections include the inability to provide long-term extraocular drug delivery without compromising intraocular structures and/or systemic drug exposure. In the present study, the potential of Eudragit RS 100 nanoparticles as a new vehicle for the improvement of the delivery of drugs to the ocular mucosa was investigated. Amphotericin-B was chosen as a model compound because of its potential usefulness for the treatment of the fungal diseases. A solvent displacement technique was used to produce Amphotericin-B loaded Eudragit nanoparticles. These nanoparticles had a mean size range of 150-290 nm, a zeta potential of + 19-28 mV. Even after 6 months of stability study results were unchanged, this was very much suitable for ocular application. In vitro release studies revealed that maximum amount of drug was released within 24hrs (60%). The results obtained from microbial assay showed that the antifungal activity of drug-loaded nanoparticles was equal or slightly lower than that of free AmB solution. In vivo experiments showed that, following topical instillation of nanosuspension to rabbit's eye, there was no irritation. From these results, we can conclude that Eudragit RS 100 nanosuspension may represent an interesting vehicle to deliver the drug in eye.
School of Pharmacy and Technology Management, NMIMS University, Mumbai, Maharastra, India.
This article was published in the following journal.
Name: Nanomedicine : nanotechnology, biology, and medicine
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20692375
- DOI: http://dx.doi.org/10.1016/j.nano.2010.07.003
Several drug delivery systems have been proposed to overcome physiological barriers, improving ocular bioavailability. Systemic routes are seldom used due to the blood-ocular barrier. Novel drug deliv...
Lacrimal dysfunction syndrome (LDS) and meibomian gland dysfunction (MGD) are common pathologies of the ocular surface both characterized by quantitative and/or qualitative tear film changings. They m...
Electrospun nanofiber drug delivery systems have been studied using various techniques. Herein, we describe the fabrication of a drug-incorporating nanofiber. Drugs, such as proteins, peptide, antibod...
Abstract Purpose: A new gel formulation containing loteprednol etabonate (LE), a C-20 ester corticosteroid used to treat ocular inflammation, was developed to provide increased retention on the ocular...
Glaucoma is a progressive optic neuropathy and medical therapy is the initial option for the treatment of this potentially blinding condition. Topical instillation of eye drops from the bottle is the...
This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries, which includes pterygium surgery, corneal melting/perforation, Gunders...
Topical fluoroquinolones (FQs) have achieved widespread use in ophthalmology for both the treatment and prophylaxis of ocular infections. The present study is set to determine the bacteri...
The purpose of this study is to analyze the effect of Zymar and Vigamox on ocular surface bacteria. We believe that Zymar will eradicate more ocular surface bacteria than Vigamox.
A double-masked, randomized, vehicle-controlled, dose-response study assessing the safety and ocular hypotensive efficacy of AR-102 in subjects with elevated intraocular pressure. The Null...
The purpose of the study is to determine if TRAVATAN Z improves ocular surface health in patients with open-angle glaucoma or ocular hypertension.
Medical and Biotech [MESH] Definitions
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
A species of gram-positive, facultatively anaerobic bacteria in the family STREPTOCOCCACEAE. It is a normal inhabitant of the human oral cavity, and causes DENTAL PLAQUE and ENDOCARDITIS. It is being investigated as a vehicle for vaccine delivery.
Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
The dioptric adjustment of the EYE (to attain maximal sharpness of retinal imagery for an object of regard) referring to the ability, to the mechanism, or to the process. Ocular accommodation is the effecting of refractive changes by changes in the shape of the CRYSTALLINE LENS. Loosely, it refers to ocular adjustments for VISION, OCULAR at various distances. (Cline et al., Dictionary of Visual Science, 4th ed)