Nanosuspension: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to Amphotericin-B.
Summary of "Nanosuspension: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to Amphotericin-B."
Present limitations in the management of ophthalmic fungal infections include the inability to provide long-term extraocular drug delivery without compromising intraocular structures and/or systemic drug exposure. In the present study, the potential of Eudragit RS 100 nanoparticles as a new vehicle for the improvement of the delivery of drugs to the ocular mucosa was investigated. Amphotericin-B was chosen as a model compound because of its potential usefulness for the treatment of the fungal diseases. A solvent displacement technique was used to produce Amphotericin-B loaded Eudragit nanoparticles. These nanoparticles had a mean size range of 150-290 nm, a zeta potential of + 19-28 mV. Even after 6 months of stability study results were unchanged, this was very much suitable for ocular application. In vitro release studies revealed that maximum amount of drug was released within 24hrs (60%). The results obtained from microbial assay showed that the antifungal activity of drug-loaded nanoparticles was equal or slightly lower than that of free AmB solution. In vivo experiments showed that, following topical instillation of nanosuspension to rabbit's eye, there was no irritation. From these results, we can conclude that Eudragit RS 100 nanosuspension may represent an interesting vehicle to deliver the drug in eye.
School of Pharmacy and Technology Management, NMIMS University, Mumbai, Maharastra, India.
This article was published in the following journal.
Name: Nanomedicine : nanotechnology, biology, and medicine
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20692375
- DOI: http://dx.doi.org/10.1016/j.nano.2010.07.003
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Medical and Biotech [MESH] Definitions
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
A species of gram-positive, facultatively anaerobic bacteria in the family STREPTOCOCCACEAE. It is a normal inhabitant of the human oral cavity, and causes DENTAL PLAQUE and ENDOCARDITIS. It is being investigated as a vehicle for vaccine delivery.
Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
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