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We are grateful for the possibility to reply the comments by Dr de la Portilla. We are conscious that 5 months, or 12 as affirmed by Dr de la Portilla, is sufficient to assess healing of an anal fistula, since intitial apparent success often diminishes with the time.1 However, in our pilot study2 , we adopted the recommendation provided by the 2007 Consensus Conference on Surgisis® AFP™ in which 3 months was the limit to consider the operation a failure.3 Moreover, we were able to make a very homogeneous selection of patients and a standardized technique of implantation and perioperative management. © 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.
Department of Surgical Sciences, Catholic University, Rome, Italy.
This article was published in the following journal.
Name: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
The study aimed to review, consolidate, and analyze the findings of studies investigating the efficacy of anal fistula plugs (AFPs) in treating fistula-in-ano in Crohn's patients.
Perianal fistula formation is a rare complication in children after rectal biopsy. Perianal fistula may become difficult to treat; therefore a lot of surgical options are present. One of these options...
The pathogenesis of cryptoglandular anal fistula (AF) is still debated. Tissue inflammation could play a primary role. The pathological process of epithelial mesenchymal transition (EMT) might be invo...
Coronary artery fistula (CAF) is a rare clinical abnormality characterized by a connection between one or more coronary arteries and an adjacent cardiac chamber or vascular structure. Although CAF com...
Esophageal atresia (EA) and tracheoesophageal fistula (TEF) consist of a spectrum of rare congenital abnormalities. Although EA surgical treatment is well established, the outcome of EA with proximal ...
Anal fistulae are a difficult problem to treat. The optimal treatment for fistula involving the anal sphincter is unclear. Two standardly used methods of treatment are the ligation of in...
The investigators propose to study the safety of autologous mesenchymal stromal cell transfer using a biomatrix (the Gore Fistula Plug) in a Phase I study using a single dose of 20 million...
The Surgisis Anal Fistula Plug study is a clinical trial conducted in Saudi Arabia to study the safety and effectiveness of the Surgisis AFP Plug in the treatment of chronic anal fistulas.
Healing anal fistulas in Crohn's patients with an anal fistula plug.
The investigators propose to study the safety of autologous mesenchymal stromal cell transfer using a biomatrix (The Gore Fistula Plug) in a Phase I study using a single dose of 20 million...
An abnormal anatomical passage between the INTESTINE, and another segment of the intestine or other organs. External intestinal fistula is connected to the SKIN (enterocutaneous fistula). Internal intestinal fistula can be connected to a number of organs, such as STOMACH (gastrocolic fistula), the BILIARY TRACT (cholecystoduodenal fistula), or the URINARY BLADDER of the URINARY TRACT (colovesical fistula). Risk factors include inflammatory processes, cancer, radiation treatment, and surgical misadventures (MEDICAL ERRORS).
An abnormal anatomical passage that connects the VAGINA to other organs, such as the bladder (VESICOVAGINAL FISTULA) or the rectum (RECTOVAGINAL FISTULA).
A fistula between the maxillary sinus and the oral cavity.
Abnormal passage communicating with the ESOPHAGUS. The most common type is TRACHEOESOPHAGEAL FISTULA between the esophagus and the TRACHEA.
A fistula between a salivary duct or gland and the cutaneous surface of the oral cavity.
An anesthesiologist (US English) or anaesthetist (British English) is a physician trained in anesthesia and perioperative medicine. Anesthesiologists are physicians who provide medical care to patients in a wide variety of (usually acute) situations. ...