Exercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers.
Summary of "Exercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers."
Elite swimmers have an increased risk of developing asthma, and exposure to chloramine is believed to be an important trigger factor. The aim of the present study was to explore pathophysiological mechanisms behind induced bronchoconstriction in swimmers exposed to chloramine, before and after swim exercise provocation as well as mannitol provocation. Urinary Clara cell protein (CC16) was used as a possible marker for epithelial stress. 101 elite aspiring swim athletes were investigated and urinary samples were collected before and 1 h after completed exercise and mannitol challenge. CC16, 11beta-prostaglandin (PG)F(2alpha) and leukotriene E(4) (LTE(4)) were measured. Urinary levels of CC16 were clearly increased after exercise challenge, while no reaction was seen after mannitol challenge. Similar to CC16, the level of 11beta-PGF(2alpha) was increased after exercise challenge, but not after mannitol challenge, while LTE(4) was reduced after exercise. There was no significant difference in urinary response between those with a negative compared to positive challenge, but a tendency of increased baseline levels of 11beta-PGF(2alpha) and LTE(4) in individuals with a positive mannitol challenge. The uniform increase of CC16 after swim exercise indicates that CC16 is of importance in epithelial stress, and may as such be an important pathogenic factor behind asthma development in swimmers. The changes seen in urinary levels of 11beta-PGF(2alpha) and LTE(4) indicate a pathophysiological role in both mannitol and exercise challenge.
Affiliation
Respiratory Medicine and Allergology, Dept. of Clinical Sciences, Lund University, Lund, Sweden; Health Care Centre, Näsets Läkargrupp, Höllviken, Sweden.
Journal Details
This article was published in the following journal.
Name: Respiratory medicine
ISSN: 1532-3064
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20696561
- DOI: http://dx.doi.org/10.1016/j.rmed.2010.07.012
Medical and Biotech [MESH] Definitions
Mannitol Phosphates
Phosphoric acid esters of mannitol.
Mannitol
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
Exercise Tolerance
The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.
Mannitol Dehydrogenases
Sugar alcohol dehydrogenases that have specificity for MANNITOL. Enzymes in this category are generally classified according to their preference for a specific reducing cofactor.
Exercise Test
Controlled physical activity, more strenuous than at rest, which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. The intensity of exercise is often graded, using criteria such as rate of work done, oxygen consumption, and heart rate.
PubMed Articles
PURPOSE: To study the impact of different process conditions and formulation compositions on metastable mannitol forms in protein formulations during lyophilization. METHODS: Mannitol was studied with...
Pelvic floor exercise for urinary incontinence: A systematic literature review.
Urinary incontinence is a common problem among adults and conservative management is recommended as the first-line treatment. Physical therapies, particularly pelvic floor muscle exercise, are the mai...
A putative mannitol operon of the phosphoenolpyruvate phosphotransferase (PTS) type was cloned from Vibrio cholerae O395, and its activity was studied in Escherichia coli. The 3.9-kb operon comprising...
Biotechnological production of mannitol and its applications.
Mannitol, a naturally occurring polyol (sugar alcohol), is widely used in the food, pharmaceutical, medical, and chemical industries. The production of mannitol by fermentation has become attractive b...
Effects of aerobic exercise on urinary estrogens and progestagens in pre and postmenopausal women.
The purpose of this study was to elucidate the effect of 6 months of aerobic exercise on urinary excretion of female steroid hormones in pre and postmenopausal women and to check the basal values of...
Clinical Trials
Chronic cough is defined by its persistence beyond 8 weeks. Many conditions can explain the existence of a bronchial inflammation. In the management of chronic cough, the search for bronch...
Hypertonic Saline 75% vs Mannitol 20%
The purpose of this study is to evaluate the effect of Hypertonic Saline 7.5% vs Mannitol 20% on brain bulk (using a 4 point scale), intracranial pressure (subdural catheter)and the change...
Exercise Induced Asthma and Airway Reactivity in Athletes
The overall aim is to explore pathophysiological factors related to airway hyperresponsiveness to direct and indirect provocation stimuli in athletes with different sport activities, with...
Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis
The purpose of this study is to determine the medium term efficacy and safety profile of inhaled mannitol, on its own and also as an additional therapy to rhDNase (pulmozyme). In particula...
The CLARA Study From the Acute Leukemia French Association (ALFA 0702 Trial)
This study is a phase II randomized multicenter study. Patients will be enrolled at time of diagnosis and will receive one or two cycles of induction chemotherapy. Patients, without indica...
