Sacral Nerve Modulation in Overactive Bladder.
Summary of "Sacral Nerve Modulation in Overactive Bladder."
This article represents a general overview of therapies for urinary urgency, frequency, and overactive bladder, with specific emphasis on sacral neuromodulation. The history of sacral neuromodulation is discussed along with an update of the current literature. Future directions for neuromodulation of the pelvic floor also are discussed.
Affiliation
Division of Gynecologic Surgery, Mayo Clinic, 200 First Street Southwest, Rochester, MN, 55905, USA, Occhino.john@gmail.com.
Journal Details
This article was published in the following journal.
Name: Current urology reports
ISSN: 1534-6285
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20635172
- DOI: http://dx.doi.org/10.1007/s11934-010-0132-6
Medical and Biotech [MESH] Definitions
Urinary Bladder, Overactive
Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. URINARY INCONTINENCE may or may not be present.
Sciatic Nerve
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Tibial Nerve
The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot.
Tarlov Cysts
Perineurial cysts commonly found in the SACRAL REGION. They arise from the PERINEURIUM membrane within the SPINAL NERVE ROOTS. The distinctive feature of the cysts is the presence of spinal nerve root fibers within the cyst wall, or the cyst cavity itself.
Cauda Equina
The lower part of the SPINAL CORD consisting of the lumbar, sacral, and coccygeal nerve roots.
PubMed Articles
Sacral neuromodulation in urology : The emperor's new clothes or effective high-tech medicine?
Sacral nerve modulation (SNM) is an innovative, minimally invasive treatment that uses chronic low-level electrical stimulation of the sacral plexus to recruit residual physiological function of urina...
The overactive bladder syndrome and detrusor overactivity are conditions that can have major effects on quality of life and social functioning. Antimuscarinic drugs are still first-line treatment. The...
Sphincteroplasty for fecal incontinence in the era of sacral nerve modulation.
The role of sphincteroplasty in the treatment of patients with fecal incontinence due to anal sphincter defects has been questioned because the success rate declines in the long-term. A new emerging t...
OBJECTIVES: Several studies discussing the pathology of overactive bladder suggested changes in urinary proteins. The neurotrophin "nerve growth factor" (NGF) seems to be an impo...
Electrical nerve stimulation for overactive bladder in children.
Overactive bladder (OAB) is a urological condition that is frequently observed in children and requires treatment. Standard urotherapy is usually the first line of treatment; however, children with se...
Clinical Trials
Sacral nerve modulation (SNM) is an established treatment for refractory lower urinary tract and bowel dysfunction (Spinelli 2008). Pudendal nerve stimulation (PNS) has been proposed for p...
Screening Method in Sacral Neuromodulation
The purpose of this study was to evaluate whether there is a difference in long-term outcome between patients screened with the percutaneous nerve evaluation (PNE) and first stage tined le...
This is a two-part study in which Part A will assess the effects of GW679769 after 1 dose on the function of the nerves that supply the bladder. The technique for measuring the nerves func...
Measuring sympathetic skin response or heart rate variability can provide an objective biomarker of bladder sensation and its modulation by drug with potential to treat overactive bladder.
This study is a retrospective chart review including all patients who received surgical placement of a SNM device with Dr. Noblett from 2001 to the present.
