Hormonal contraception in women with the metabolic syndrome: A narrative review.

16:18 EDT 1st October 2014 | BioPortfolio

Summary of "Hormonal contraception in women with the metabolic syndrome: A narrative review."

Objective The metabolic syndrome (MS) is a set of five cardiovascular and metabolic risk factors: elevated waist circumference, fasting plasma glucose, triglycerides and blood pressure; and reduced HDL-cholesterol. The prevalence of the MS is rising worldwide, and is linked to two diagnoses in young women: polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM). Methods This narrative review focuses on hormonal contraceptive choices available for women in Europe with features of the MS. Results The levonorgestrel-intrauterine system and progestogen-only pills containing desogestrel or levonorgestrel have no significant effects on MS parameters. Combined oestrogen-progestogen methods do not appear to increase waist circumference or the incidence of glucose intolerance in women with PCOS or a history of GDM; their effect on HDL-cholesterol and triglycerides is comparable with that observed in women without the MS, while the effect on blood pressure remains inconclusive. The etonogestrel implant does not affect body weight, triglycerides and blood pressure but mildly reduces insulin sensitivity and HDL-cholesterol in healthy women. Depot medroxyprogesterone acetate increases body weight and truncal fat deposition, and lowers glucose tolerance in women with previous GDM. Conclusions Low-dose hormonal contraception is safe for many women with the MS, but high-dose progestogens must be avoided.

Affiliation

Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium.

Journal Details

This article was published in the following journal.

Name: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
ISSN: 1473-0782
Pages:

Links

PubMed Articles [23648 Associated PubMed Articles listed on BioPortfolio]

Anti-epileptic drugs and hormonal treatments.

Epilepsy and the medications used in its treatment are known to affect the menstrual cycle, aspects of contraception, and bone health in women. Adolescence is an important time to review the diagnosis...

Repeated use of pre- and postcoital hormonal contraception for prevention of pregnancy.

Repeated use of postcoital hormonal contraception is not currently recommended due to the higher risk of side effects and lower contraceptive effectiveness compared to other modern methods of contrace...

Obesity and Contraception.

Utilizing contraception is critical in preventing unintended pregnancies among obese women. However, clinicians and obese patients may be unclear about which contraceptive methods are optimal. This re...

Contraception, punishment and women who use drugs.

In light of the recent debate on the use of financial incentives to promote long-acting contraception and sterilisation among women who use illicit drugs we discuss attitudes to contraception, pregnan...

A single-arm study to evaluate the efficacy, safety and acceptability of pericoital oral contraception with levonorgestrel.

An oral dose of 0.75 mg levonorgestrel (LNG) taken shortly after sex was marketed as a routine, nonemergency contraceptive method until the 1990s. Because a hormonal method used only at the time of in...

Clinical Trials [5254 Associated Clinical Trials listed on BioPortfolio]

Substrate Utilization and Hormonal Status in Women

Women sexual hormones (i.e. estrogen) are involved in the regulation of substrate utilization and storage. Being under oral contraception (OC) may conduct to metabolic and hormonal modific...

Computer-Assisted Provision of Reproductive Health Care

This project seeks to demonstrate that computer kiosks in a clinic waiting room can improve access to hormonal contraception and screening for sexually transmitted infections. The study wi...

A Randomized Trial of IUD Versus Hormonal Contraception in HIV-infected Women in Zambia

A randomized trial of the intrauterine contraceptive device (IUD) versus user's choice hormonal contraception (injectable progestins or oral contraceptive pills) among HIV-infected, recent...

Effect of Berberine on Hormonal and Metabolic Features in Obese Women With Polycystic Ovary Syndrome (PCOS)

Berberine has showed effective in lowering blood sugar levels in db/db mice and anti-dyslipidemia in human.Studies on the effect of berberine on metabolic and hormonal features of women wi...

Impact of Different Contraceptives on the Immune System of HIV Infected Women in Zambia

In this study, 66 HIV-infected women who desire contraception will be randomly assigned to use either an IUD or Depo Provera, and will be followed for six months. The study is intended to...

Medical and Biotech [MESH] Definitions

A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)

Methods of contraception in which physical, chemical, or biological means are used to prevent the SPERM from reaching the fertilizable OVUM.

Review of the medical necessity of hospital or other health facility admissions, upon or within a short time following an admission, and periodic review of services provided during the course of treatment.

A condition of having excess fat in the abdomen. Abdominal obesity is typically defined as waist circumferences of 40 inches or more in men and 35 inches or more in women. Abdominal obesity raises the risk of developing disorders, such as diabetes, hypertension and METABOLIC SYNDROME X.

Formal programs for assessing drug prescription against some standard. Drug utilization review may consider clinical appropriateness, cost effectiveness, and, in some cases, outcomes. Review is usually retrospective, but some analysis may be done before drugs are dispensed (as in computer systems which advise physicians when prescriptions are entered). Drug utilization review is mandated for Medicaid programs beginning in 1993.

Search BioPortfolio:
Loading
Advertisement

Relevant Topics

Women's Health
Latest News Clinical Trials Research Drugs Reports Corporate
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Cardiovascular disease (CVD)
Latest News Clinical Trials Research Drugs Reports Corporate
Cardiovascular disease (CVD) includes all the diseases of the heart and circulation including coronary heart disease (angina and heart attack), heart failure, congenital heart disease and stroke. It is also known as heart and circulatory disease. Coron...

Blood
Latest News Clinical Trials Research Drugs Reports Corporate
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Advertisement