Advertisement

Topics

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome.

06:00 EDT 12th August 2010 | BioPortfolio

Summary of "Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome."

To resolve the genetic heterogeneity within pediatric high-risk B-precursor acute lymphoblastic leukemia (ALL), a clinically defined risk group with few known recurring cytogenetic abnormalities and a poor outcome, we performed gene expression profiling (GEP) in a cohort of 207 uniformly treated children with high-risk ALL. Expression profiles were correlated with genome-wide DNA copy number abnormalities and clinical and outcome features. Unsupervised clustering of GEP data revealed eight unique cluster groups within these high-risk ALL patients, two of which were associated with known chromosomal translocations (t(1;19)(TCF3-PBX1) or MLL), and six of which lacked any previously known cytogenetic lesion. One unique cluster was characterized by high expression of distinct outlier genes AGAP1, CCNJ, CHST2/7, CLEC12A/B and PTPRM; ERG DNA deletions; and a 4-year relapse-free survival (RFS) of 94.7+/-5.1%, compared to 63.5+/-3.7% for the cohort (P=0.01). A second cluster, characterized by high expression of BMPR1B, CRLF2, GPR110, MUC4; frequent deletion of EBF1, IKZF1, RAG1-2, and IL3RA-CSF2RA; JAK mutations and CRLF2 rearrangements (P<.0001); and Hispanic ethnicity (P<.001), had a very poor 4-year RFS (21.0+/-9.5%; P<.001). These studies reveal the striking clinical and genetic heterogeneity in high-risk ALL and point to novel genes which may serve as new targets for diagnosis, risk classification, and therapy.

Affiliation

The University of New Mexico Cancer Center and Departments of Pathology, Internal Medicine, Mathematics & Statistics, and Physics & Astronomy, University of New Mexico, Albuquerque, NM;

Journal Details

This article was published in the following journal.

Name: Blood
ISSN: 1528-0020
Pages:

Links

DeepDyve research library

PubMed Articles [40495 Associated PubMed Articles listed on BioPortfolio]

miR expression profiling at diagnosis predicts relapse in pediatric precursor B-cell acute lymphoblastic leukemia.

Our aim was to identify miRNAs that can predict risk of relapse in pediatric patients with acute lymphoblastic leukemia (ALL). Following high-throughput miRNA expression analysis (48 samples), five mi...

Survival of high-risk pediatric neuroblastoma patients in a developing country.

Little information is available about survival of high-risk pediatric neuroblastoma patients in developing countries. We aimed to assess survival among high-risk pediatric neuroblastoma patients in La...

Characteristics and pre-travel preparation of travelers at a Canadian pediatric tertiary care travel clinic: A retrospective analysis.

International travelers are susceptible to a wide spectrum of travel related morbidities. Despite rising number of international travelers in Canada, the demographics, risk profiles, and preventative ...

Risk factors for venous thromboembolism after pediatric trauma.

The purposes of this study were to identify independent predictors of venous thromboembolism (VTE), to evaluate the relative impact of adult VTE risk factors, and to identify a pediatric population at...

Personality profiles in young adults with disordered eating behavior.

Personality traits are closely related to eating disorders (ED) and might be involved in their development and maintenance. Nevertheless little is known regarding the association between personality t...

Clinical Trials [8587 Associated Clinical Trials listed on BioPortfolio]

EBV Infection as a Risk Factor for PTLD in Pediatric and Adult Renal Transplant Recipients

Question: In which stage of an EBV-infection is a selective reduction of immunosuppressive medication reasonable to minimize the risk for PTLD, without putting the transplant recipient at...

A Multi-Center Study Evaluating KTE-C19 in Pediatric and Adolescent Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia

This is a single arm, open-label, multi-center, phase 1/2 study, to determine the safety and efficacy of KTE-C19, an autologous anti-CD19 chimeric antigen receptor (CAR)-positive T cell th...

Natural History of Oro-pharyngeal Cancer Precursors

Oro-pharyngeal cancers can develop from squamous dysplastic precursor lesions, which occur in a subset of common white (leukoplakia), red (erythroplasia), or mixed oro-pharyngeal plaques. ...

International CAPS Registry: Pancreas Cancer Cases in Surveillance Programs

Various centers around the world are currently investigating the feasibility and yield of surveillance for pancreatic cancer in high-risk individuals. Evidence is beginning to accumulate t...

Reducing Diagnostic Errors in Primary Care Pediatrics (Project RedDE)

The proposal will focus on 3 specific, high-risk, pediatric ambulatory diagnostic errors each representing a unique dimension of diagnostic assessment: evaluation of symptoms, evaluation o...

Medical and Biotech [MESH] Definitions

Reduction of high-risk choices and adoption of low-risk quantity and frequency alternatives.

Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).

An organization of insurers or reinsurers through which particular types of risk are shared or pooled. The risk of high loss by a particular insurance company is transferred to the group as a whole (the insurance pool) with premiums, losses, and expenses shared in agreed amounts.

Removal of a drug from the market due to the identification of an intrinsic property of the drug that results in a serious risk to public health.

Any system which allows payors to share some of the financial risk associated with a particular patient population with providers. Providers agree to adhere to fixed fee schedules in exchange for an increase in their payor base and a chance to benefit from cost containment measures. Common risk-sharing methods are prospective payment schedules (PROSPECTIVE PAYMENT SYSTEM), capitation (CAPITATION FEES), diagnosis-related fees (DIAGNOSIS-RELATED GROUPS), and pre-negotiated fees.

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topics

Pediatrics
Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

Bioinformatics
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...


Searches Linking to this Article