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The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs-studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice.

08:00 EDT 24th April 2013 | BioPortfolio

Summary of "The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs-studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice."

It is well known that somatotrophic/insulin signaling affects lifespan in experimental animals. To study the effects of insulin-like growth factor-1 (IGF-1) plasma level on the morphology of major organs, we analyzed lung, heart, liver, kidney, bone marrow, and spleen isolated from 2-year-old growth hormone receptor knockout (GHR-KO) Laron dwarf mice (with low circulating plasma levels of IGF-1) and 6-month-old bovine growth hormone transgenic (bGHTg) mice (with high circulating plasma levels of IGF-1). The ages of the two mutant strains employed in our studies were selected based on their overall ~50% survival (Laron dwarf mice live up to ~4 years and bGHTg mice up to ~1 year). Morphological analysis of the organs of long-living 2-year-old Laron dwarf mice revealed a lower biological age for their organs compared with normal littermates, with more brown adipose tissue (BAT) surrounding the main body organs, lower levels of steatosis in liver, and a lower incidence of leukocyte infiltration in different organs. By contrast, the organs of 6-month-old, short-living bGHTg mice displayed several abnormalities in liver and kidney and a reduced content of BAT around vital organs.

Affiliation

Department of Physiology Pomeranian Medical University, Szczecin, Poland.

Journal Details

This article was published in the following journal.

Name: Histology and histopathology
ISSN: 1699-5848
Pages:

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