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Beyond gout: uric acid and cardiovascular diseases.

08:00 EDT 24th April 2013 | BioPortfolio

Summary of "Beyond gout: uric acid and cardiovascular diseases."

Abstract Objectives: This article discusses the results of clinical and experimental studies that examine the association of hyperuricemia and gout with cardiovascular (CV) disease. Methods: Key papers for inclusion were identified by a PubMed search, and articles were selected for their relevance to the topic, according to the authors' judgment. Results and conclusions: Significant progress has been made in confirming an association, possibly causal, between hyperuricemia and CV outcomes. Xantine-oxidase (XO) inhibitors appear to be the most promising agents for prevention and treatment of CV consequences associated with hyperuricemia. Several small and medium sized studies have examined the effect of these agents on CV function in a variety of patient populations. Improvements in measures of endothelial function, oxidative stress, cardiac function, hemodynamics, and certain inflammatory indices have been demonstrated. Compounds for XO inhibition with more specific clinical effects and fewer side effects than allopurinol may be promising options to further explore the therapeutic potential in patients with CV disease. It is too early to make clinical recommendations with regard to the benefits of using XO inhibitor allopurinol or the novel febuxostat in patients with asymptomatic increased UA levels and high CV risk because only a small number of studies have shown that they may be beneficial in terms of CV outcomes. More studies are therefore needed to determine the potential of these drugs for reducing the risk of developing CV disease.

Affiliation

Division of Medicine and Surgery , Spedali Civili, Brescia , Italy.

Journal Details

This article was published in the following journal.

Name: Current medical research and opinion
ISSN: 1473-4877
Pages:

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PubMed Articles [19267 Associated PubMed Articles listed on BioPortfolio]

Hyperuricemia-Related Diseases and Xanthine Oxidoreductase (XOR) Inhibitors: An Overview.

Uric acid is the final oxidation product of purine metabolism in humans. Xanthine oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric acid, accompanying the prod...

Hot Topics in Primary Care: Update on the Recognition and Management of Gout: More Than the Great Toe.

Gout is a rheumatic disease resulting from chronic deposition of uric acid crystals as monosodium urate (MSU) in tissues and joints causing joint pain and swelling that, over time, may result in perma...

Hyperuricemia and nonalcoholic fatty liver disease: from bedside to bench and back.

Uric acid is the end product of dietary or endogenous purines degradation, and hyperuricemia is one of the most common metabolic disorders. It has been widely accepted that hyperuricemia increases ris...

Serum uric acid levels and mortality in the Japanese population: the Yamagata (Takahata) study.

Serum uric acid level is regulated by gender, dietary habit, genetic predisposition, and renal function, and is associated with the development of renal and cardiovascular diseases. This study prospec...

Sensitivity and specificity of ultrasonographic features of gout in intercritical and chronic phase.

This study aimed to assess the sensitivity and specificity of ultrasonographic features of gout in intercritical and chronic stages and compared ultrasonographic features of gout between patients with...

Clinical Trials [5109 Associated Clinical Trials listed on BioPortfolio]

The Effects of Different Kinds of Antihypertensive Drugs on Uric Acid in Plasma

Hypertension is one of the most common cardiovascular diseases, which is a major risk factor for stroke and cardiovascular events. Recent studies found that the occurrence and development ...

Optimal Administration of Allopurinol in Dialysis Patients

Gout has a strong association with the metabolic syndrome, and it is often seen in patients with renal insufficiency. Allopurinol is a medication intended to lower uric acid and therefore ...

Pegylated Recombinant Mammalian Uricase (PEG-uricase) as Treatment for Refractory Gout

The purpose of this study is to determine whether PEG-uricase (a chemically modified recombinant mammalian enzyme that degrades uric acid) is effective in controlling hyperuricemia in pati...

A Study of Persons With Gout Who Do Not Respond to or Are Allergic to Conventional Therapy

This is a randomized, open-label, multicenter, parallel-groups study of multiple intravenous doses of Puricase, administered intravenously, in 40 patients with symptomatic gout. Subjects m...

Gout: Allopurinol vs. Febuxostat

This trial will compare two effective therapies, allopurinol and febuxostat, to lower serum uric acid and therefore prevent further gout attaches. These therapies have never been compared ...

Medical and Biotech [MESH] Definitions

Agents that increase uric acid excretion by the kidney (URICOSURIC AGENTS), decrease uric acid production (antihyperuricemics), or alleviate the pain and inflammation of acute attacks of gout.

Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.

Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.

Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.

Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.

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