Therapeutic Drug Monitoring of Clonazepam.

09:17 EDT 31st August 2015 | BioPortfolio

Summary of "Therapeutic Drug Monitoring of Clonazepam."

Clonazepam is a 1-4 benzodiazepine mainly used to treat epilepsy and epileptiform convulsion state. Rapidly absorbed after oral administration, it is widely distributed in the organism and is extensively converted in metabolites, poorly or not active, eliminated mainly in urine (70%) and feces. Elimination half-life is long, around 40 h. In adult and child, several studies showed a concentration-effect relation. Meanwhile, a large inter-individual variability in the dose-concentration relation was observed. A 15-50 mug/L range of clonazepam blood concentrations appears to be retained as an acceptable target to control a majority of epileptic seizures. The Therapeutic Drug Monitoring (TDM) of clonazepam can be considered as possibly useful in case of association with CYP450 inducers or inhibitors, suspicion of poor observance, or toxicity signs.


Service de Pharmacologie-Toxicologie, CHU Côte de Nacre, Caen, France.

Journal Details

This article was published in the following journal.

Name: Therapie
ISSN: 0040-5957
Pages: 219-224


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Medical and Biotech [MESH] Definitions

Measurable biological parameters that serve for drug development, safety and dosing (DRUG MONITORING).

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The process of observing, recording, or detecting the effects of a chemical substance administered to an individual therapeutically or diagnostically.

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The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.


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Epilepsy is defined as a disorder of brain function characterized by recurrent seizures that have a sudden onset.  (Oxford Medical Dictionary).  A seizure is caused by a sudden burst of excess electrical activity in the brain, causing a tempora...