Advertisement

Topics

Therapeutic Drug Monitoring of Clonazepam.

Summary of "Therapeutic Drug Monitoring of Clonazepam."

Clonazepam is a 1-4 benzodiazepine mainly used to treat epilepsy and epileptiform convulsion state. Rapidly absorbed after oral administration, it is widely distributed in the organism and is extensively converted in metabolites, poorly or not active, eliminated mainly in urine (70%) and feces. Elimination half-life is long, around 40 h. In adult and child, several studies showed a concentration-effect relation. Meanwhile, a large inter-individual variability in the dose-concentration relation was observed. A 15-50 mug/L range of clonazepam blood concentrations appears to be retained as an acceptable target to control a majority of epileptic seizures. The Therapeutic Drug Monitoring (TDM) of clonazepam can be considered as possibly useful in case of association with CYP450 inducers or inhibitors, suspicion of poor observance, or toxicity signs.

Affiliation

Service de Pharmacologie-Toxicologie, CHU Côte de Nacre, Caen, France.

Journal Details

This article was published in the following journal.

Name: Therapie
ISSN: 0040-5957
Pages: 219-224

Links

DeepDyve research library

PubMed Articles [16969 Associated PubMed Articles listed on BioPortfolio]

Voriconazole therapeutic drug monitoring practices in the intensive care.

Routine therapeutic drug monitoring of voriconazole appears to be beneficial. This study investigated the therapeutic drug monitoring practices in intensive care to derive possible recommendations for...

Determination of common antipsychotics in QuantisalTM-collected oral fluid by UHPLC-MS/MS: method validation and applicability for therapeutic drug monitoring.

Oral fluid (OF) is an interesting alternative for conventional blood testing in therapeutic drug monitoring (TDM). OF can be used for screening but its value for quantification has to be established.

Therapeutic Drug Monitoring of Pentobarbital: Experience at an Academic Medical Center.

Pentobarbital is used for management of intractable seizures and for reducing elevated intracranial pressure. Dosing of pentobarbital can be aided by therapeutic drug monitoring (TDM). There is no com...

Relationship of sulfamethoxazole therapeutic drug monitoring to clinical efficacy and toxicity: a retrospective cohort study.

Trimethoprim/sulfamethoxazole (TMP/SMX) is the treatment of choice for infections caused by Pneumocystis jiroveci, Stenotrophomonas maltophilia, and Nocardia species, but the utility of therapeutic dr...

Evaluation of the Waters MassTrak LC-MS/MS Assay for Tacrolimus and a Comparison to the Abbott Architect Immunoassay.

Tacrolimus (Prograf®, Advagraf®, FK-506) is the most commonly prescribed calcineurin inhibitor following kidney and liver transplantation. The use of tacrolimus (in conjunction with other drugs) has...

Clinical Trials [2834 Associated Clinical Trials listed on BioPortfolio]

Study of Antiepileptic Drug in Generalised Convulsive Status Epileptics

Compare the efficiency of the association, first line, the intravenous levetiracetam and the intravenous clonazepam, in that of a monotherapy of clonazepam intravenous in the pre-hospital ...

Effectiveness of Mucolox® and Clonazepam in Treatment of Burning Mouth Syndrome

What affect does the use of a mucoadhesive drug delivery system (Mucolox®) compounded with clonazepam have in the treatment of burning mouth syndrome? There are no clinical trials report...

Study of Intranasal Clonazepam in Adult Subjects With Epileptic Seizures

Evaluate the safety and efficacy of intranasal Clonazepam in subjects with epilepsy.

Bioavailability Study of Clonazepam ODT Under Fasting Conditions

To compare the single-dose bioavailability of Clonazepam ODT 1 mg and Klonopin Wafers 1 mg ODT

Bioavailability Study of Clonazepam Tablets Under Fasting Conditions

To compare the single-dose bioavailability of Clonazepam tablets 1 mg and Klonopin tablets 1 mg

Medical and Biotech [MESH] Definitions

Measurable biological parameters that serve for drug development, safety and dosing (DRUG MONITORING).

Physiologic or biochemical monitoring of the fetus. It is usually done during LABOR, OBSTETRIC and may be performed in conjunction with the monitoring of uterine activity. It may also be performed prenatally as when the mother is undergoing surgery.

The process of observing, recording, or detecting the effects of a chemical substance administered to an individual therapeutically or diagnostically.

Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.

The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topics

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

Epilepsy
Epilepsy is defined as a disorder of brain function characterized by recurrent seizures that have a sudden onset.  (Oxford Medical Dictionary).  A seizure is caused by a sudden burst of excess electrical activity in the brain, causing a tempora...