A Biodegradable and Biocompatible Drug-Delivery System Based on Polyoxalate Microparticles.
Summary of "A Biodegradable and Biocompatible Drug-Delivery System Based on Polyoxalate Microparticles."
Drug delivery using biodegradable polymeric microparticles is becoming an important means of delivering therapeutic agents. In this work, we describe polyoxalate microparticles as a biodegradable and biocompatible protein drug-delivery system. Polyoxalate was synthesized from a polycondensation reaction between oxalyl chloride and 1,4-cyclohexanedimethanol under basic conditions. Polyoxalate, in design, undergoes hydrolytic degradation to generate non-toxic low-molecular-weight compounds that can be easily excreted from a body. Polyoxalate was hydrophobic and had a half-life of 6.5 days at pH 7.4. This hydrophobic polyoxalate could be formulated into microparticles by a double emulsion method and encapsulate proteins with a loading efficiency of more than 80%. Cytotoxicity evaluation using RAW 264.7 cells indicated that polyoxalate microparticles exhibited a cytotoxicity profile superior to PLGA microparticles. The polyoxalate microparticles were taken up by macrophages in vitro as confirmed by confocal fluorescence microscopy. The ease of synthesis coupled with the physicochemical properties and excellent biocompatibility make this polyoxalate a promising candidate for protein-delivery applications.
Affiliation
Journal Details
This article was published in the following journal.
Name: Journal of biomaterials science. Polymer edition
ISSN: 1568-5624
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20699060
- DOI: http://dx.doi.org/10.1163/092050610X519480
Medical and Biotech [MESH] Definitions
Drug Carriers
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Drug Delivery Systems
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Nanospheres
Spherical particles of nanometer dimensions. They are biodegradable and self-assembling and have potential as DRUG CARRIERS and imaging agents.
Cell-derived Microparticles
Extracellular membrane vesicles generated by the shedding of CELL MEMBRANES blebs. Microparticles originating from PLATELETS; ENDOTHELIAL CELLS; and other cell types circulate in the peripheral blood and through the MICROVASCULATURE where larger cells cannot, functioning as active effectors in a variety of vascular processes such as INFLAMMATION; HEMOSTASIS; angiogenesis; and vascular reactivity. Increased levels are found following stimulation of bleb formation under normal or pathological conditions.
Liposomes
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
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