Coagulopathy and platelet disorders in critically ill patients.
Summary of "Coagulopathy and platelet disorders in critically ill patients."
Coagulation disorders are common among intensive care patients and may range from isolated thrombocytopenia or prolonged global clotting tests to complex defects, such as disseminated intravascular coagulation. There are many causes for deranged coagulation in critically ill patients and each of these underlying disorders may require specific therapeutic management. Hence, a proper differential diagnosis and the initiation of adequate (supportive) treatment strategies are crucial to reduce morbidity and mortality in critically ill patients with coagulation abnormalities.
Affiliation
Department of Vascular Medicine and Internal Medicine, Academic Medical Center, University of Amsterdam, the Netherlands - m.m.levi@amc.uva.nl.
Journal Details
This article was published in the following journal.
Name: Minerva anestesiologica
ISSN: 1827-1596
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20634789
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Blood Platelet Disorders
Disorders caused by abnormalities in platelet count or function.
Trazodone
A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
Blood Coagulation Disorders
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
Gray Platelet Syndrome
A rare, inherited platelet disorder characterized by a selective deficiency in the number and contents of platelet alpha-granules. It is associated with THROMBOCYTOPENIA, enlarged platelets, and prolonged bleeding time.
Apache
An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.
PubMed Articles
Bleeding and coagulation disorders in tonsillectomies.
BACKGROUND: The aim of our prospective analysis was to show the incidence of bleeding disorders among a tonsillectomy patient population and in case of bleeding disorders. PATIENTS AND METHODS: This s...
Optimization of thromboelastography-guided platelet transfusion in cardiovascular surgery.
OBJECTIVES: Platelet dysfunction is a major cause of bleeding complications in patients undergoing cardiovascular surgery under cardiopulmonary bypass (CPB). Thromboelastography (TEG) can be used to a...
Increased and decreased levers of platelet monoamine oxidase (MAO) activity have been reported in patients with eating disorders, indicating abnormalities of the serotonin turnover. However, whether t...
Thrombocytopenia develops early in malaria, but the underlying mechanisms remain incompletely understood. We studied the aetiology of malaria-associated thrombocytopenia in volunteers experimentally i...
Characterization of platelet dysfunction after trauma.
The increased morbidity and mortality associated with coagulopathy and thrombocytopenia after trauma are well described. However, few studies have assessed platelet function after injury.
Clinical Trials
Platelet Count Trends in Pre-eclamptic Parturients
Thrombocytopenia (platelet count < 100,000/mL) occurs in approximately 15% of women with preeclampsia. Neuraxial analgesia is contraindicated in parturients with a coagulopathy; therefore,...
Oral Melatonin in Critically Ill High-Risk Patients
Sleep disruptions are extremely common in high-risk critically ill patients. We want to analyse oral melatonin potentialities as a sedative and a free-radicals scavenger for critically ill...
Transfusion of Fresh Frozen Plasma in Non-bleeding Intensive Care Unit (ICU) Patients
With the aim to restrict inappropriate fresh frozen plasma (FFP) transfusions to critically ill patients, a randomized clinical trial will be conducted in a subgroup of intensive care (ICU...
ARC1779 Injection in Patients With Von Willebrand Factor-Related Platelet Function Disorders
To evaluate the overall safety and tolerability of ARC1779, a therapeutic oligonucleotide ("aptamer") in patients with three types of von Willebrand Factor related platelet disorders.
The purpose of this study is to evaluate efficacy, safety and tolerance of Beriplex® P/N compared with plasma in regard to rapid reversal of coagulopathy induced by vitamin K antagonists...
