Morphine or oxycodone tablets for pain?
Summary of "Morphine or oxycodone tablets for pain?"
The opioids morphine and oxycodone are potent analgesics that are available as extended-release and immediate-release tablets. Indications are the same for both; i.e. severe acute pain and chronic pain (non-malignant or malignant). Few clinical studies have compared morphine and oxycodone directly. There is no evidence to support that one is superior over the other.
Affiliation
olav.m.fredheim@ntnu.no Nasjonalt kompetansesenter for sammensatte lidelser og Norges teknisk-naturvitenskapelige universitet og Klinikk for akuttmedisin Sykehuset Telemark.
Journal Details
This article was published in the following journal.
Name: Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
ISSN: 0807-7096
Pages: 1479-81
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20706310
- DOI: http://dx.doi.org/10.4045/tidsskr.09.1143
Medical and Biotech [MESH] Definitions
Meperidine
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Oxymorphone
An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)
Tablets, Enteric-coated
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
Tilidine
An opioid analgesic used similarly to MORPHINE in the control of moderate to severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1097)
Morphine
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
PubMed Articles
Summary Oxycodone's respiratory profile (particularly the extent of respiratory depression in comparison to morphine) remains to be fully characterised in the peri-operative period. We randomly assign...
Studies have demonstrated that clonidine (α(2)-adrenoceptor and imidazoline receptor agonist) and BMS182874 (endothelin ET(A) receptor antagonist) potentiate morphine and oxycodone analgesia. Agmatin...
Anomalous observations of hydrocodone in patients on oxycodone.
BACKGROUND: Urine drug monitoring is used by physicians treating chronic pain patients with opioid therapy. Patients are tested in part to insure that they are not taking other drugs. Therefore, the f...
Opioid formulations designed to resist/deter abuse.
Physicians who prescribe opioid analgesics for patients with moderate to severe chronic pain face a balancing act in the wake of the current publicity regarding abuse (nonmedical use) of prescription...
We have previously shown that paracetamol has an opioid-sparing effect in tonsillectomy, and now we evaluated the analgesic efficacy of paracetamol i.v. in early postoperative pain after laparoscopic...
Clinical Trials
Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer
RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in...
OXY-1: The Pharmacogenetics of Oxycodone Analgesia in Postoperative Pain
Patients undergoing surgery (thyroidectomy and hysterectomy) will postoperatively receive oxycodone intravenously (IV) as pain management with morphine as an escape medicine, if there is i...
This is a randomized, double-blind, multicenter, fixed dose factorial study of Q8003 12 mg/8 mg and Q8003 6 mg/4 mg versus its individual morphine sulfate and oxycodone hydrochloride compo...
Oxycodone-naloxone in Relieving Opioid-related Constipation
The primary objective of this study is to demonstrate that subjects with moderate to severe non-malignant pain taking oxycodone/naloxone prolonged release tablets have improvement in sympt...
Oxycodone or Standard Pain Therapy in Treating Patients With Cancer Pain
RATIONALE: Oxycodone helps lessen pain caused by cancer and may improve quality of life. It is not yet known whether oxycodone works better and is more cost effective than standard therapy...
