Diabetic ketoacidosis as the first manifestation of a mixed growth hormone and prolactin-secreting tumor.
Summary of "Diabetic ketoacidosis as the first manifestation of a mixed growth hormone and prolactin-secreting tumor."
No Summary Available
Affiliation
Servicio de Endocrinología y Nutrición, Hospital La Moraleja, Madrid, España.
Journal Details
This article was published in the following journal.
Name: Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion
ISSN: 1579-2021
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20705526
- DOI: http://dx.doi.org/10.1016/j.endonu.2010.06.008
Medical and Biotech [MESH] Definitions
Receptors, Prolactin
Labile proteins on or in prolactin-sensitive cells that bind prolactin initiating the cells' physiological response to that hormone. Mammary casein synthesis is one of the responses. The receptors are also found in placenta, liver, testes, kidneys, ovaries, and other organs and bind and respond to certain other hormones and their analogs and antagonists. This receptor is related to the growth hormone receptor.
Hyperpituitarism
Disease of the glandular, anterior portion of the pituitary (PITUITARY GLAND, ANTERIOR) resulting in hypersecretion of ADENOHYPOPHYSEAL HORMONES such as GROWTH HORMONE; PROLACTIN; THYROTROPIN; LUTEINIZING HORMONE; FOLLICLE STIMULATING HORMONE ; and ADRENOCORTICOTROPIC HORMONE. Hyperpituitarism usually is caused by a functional ADENOMA.
Placental Lactogen
A polypeptide hormone of approximately 25 kDa that is produced by the SYNCYTIOTROPHOBLASTS of the PLACENTA, also known as chorionic somatomammotropin. It has both GROWTH HORMONE and PROLACTIN activities on growth, lactation, and luteal steroid production. In women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. Placental lactogen is also an insulin antagonist.
Prolactin-releasing Hormone
A hypothalamic hormone that is synthesized as a precursor protein which is cleaved into two peptides. In addition to stimulating PROLACTIN release the peptides bind to specific G-PROTEIN-COUPLED RECEPTORS found at locations within the BRAIN.
Prolactin
A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
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