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Helicobacter pylori infection concomitant with metabolic syndrome further increase risk of colorectal adenomas.

06:00 EDT 11th August 2010 | BioPortfolio

Summary of "Helicobacter pylori infection concomitant with metabolic syndrome further increase risk of colorectal adenomas."


AIM:
To investigate the association of colorectal adenomas with both Helicobacter pylori (H. pylori) infection and metabolic syndrome.
METHODS:
Using a cross-sectional hospital-based study, we analyzed physical examination data from 9311 healthy subjects with overnight physical examinations performed between January 2004 and December 2006. Examined data included gender, age, life style, anthropometric measurements, blood pressure, biochemical and hematological studies, H. pylori infection detected by esophagogastroduodenoscopy and biopsy urease tests, and colorectal adenomas detected with a complete total colonoscopy.
RESULTS:
The prevalence values for H. pylori infection, metabolic syndrome, and colorectal adenoma were 39.2%, 18.7%, and 20.7%, respectively. Colorectal adenoma risk factors included male gender [odd ratio (OR): 2.005, 95% confidence interval (CI): 1.740-2.310, P < 0.001], advanced age (
OR:
1.046, 95%
CI:
1.040-1.052, P < 0.001), smoking (
OR:
1.377, 95%
CI:
1.146-1.654, P = 0.001), increased body fat (
OR:
1.016, 95%
CI:
1.007-1.026, P = 0.001), higher white blood cell count (
OR:
1.038, 95%
CI:
1.005-1.073, P = 0.025), H. pylori infection (
OR:
1.366, 95%
CI:
1.230-1.517, P < 0.001), and metabolic syndrome (
OR:
1.408, 95%
CI:
1.231-1.610, P < 0.001). In addition, concomitant H. pylori infection with metabolic syndrome further increased the probability of colorectal adenomas.
CONCLUSION:
Our study revealed H. pylori infection with concomitant metabolic syndrome might further increase the risk of colorectal adenomas.

Affiliation

Department of Anatomic Pathology, Buddhist Dalin Tzu Chi General Hospital, 2, Min-Sheng Road, Dalin, Chiayi 62247, Taiwan, China. p121521@gmail.com.

Journal Details

This article was published in the following journal.

Name: World journal of gastroenterology : WJG
ISSN: 1007-9327
Pages: 3841-6

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Medical and Biotech [MESH] Definitions

Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.

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A species of gram-negative, spiral-shaped bacteria found in the gastric mucosa that is associated with chronic antral gastritis. This bacterium was first discovered in samples removed at endoscopy from patients investigated for HELICOBACTER PYLORI colonization.

Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

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