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To investigate the association of colorectal adenomas with both Helicobacter pylori (H. pylori) infection and metabolic syndrome.
Using a cross-sectional hospital-based study, we analyzed physical examination data from 9311 healthy subjects with overnight physical examinations performed between January 2004 and December 2006. Examined data included gender, age, life style, anthropometric measurements, blood pressure, biochemical and hematological studies, H. pylori infection detected by esophagogastroduodenoscopy and biopsy urease tests, and colorectal adenomas detected with a complete total colonoscopy.
The prevalence values for H. pylori infection, metabolic syndrome, and colorectal adenoma were 39.2%, 18.7%, and 20.7%, respectively. Colorectal adenoma risk factors included male gender [odd ratio (OR): 2.005, 95% confidence interval (CI): 1.740-2.310, P < 0.001], advanced age (
1.040-1.052, P < 0.001), smoking (
1.146-1.654, P = 0.001), increased body fat (
1.007-1.026, P = 0.001), higher white blood cell count (
1.005-1.073, P = 0.025), H. pylori infection (
1.230-1.517, P < 0.001), and metabolic syndrome (
1.231-1.610, P < 0.001). In addition, concomitant H. pylori infection with metabolic syndrome further increased the probability of colorectal adenomas.
Our study revealed H. pylori infection with concomitant metabolic syndrome might further increase the risk of colorectal adenomas.
Department of Anatomic Pathology, Buddhist Dalin Tzu Chi General Hospital, 2, Min-Sheng Road, Dalin, Chiayi 62247, Taiwan, China. firstname.lastname@example.org.
This article was published in the following journal.
Name: World journal of gastroenterology : WJG
To investigate the prevalence of metabolic syndrome (MS) and its components in patients with Helicobacter pylori that was detected using histopathological diagnostic methods.
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A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
A species of gram-negative, spiral-shaped bacteria found in the gastric mucosa that is associated with chronic antral gastritis. This bacterium was first discovered in samples removed at endoscopy from patients investigated for HELICOBACTER PYLORI colonization.
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