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Genetic Deficiency of Plasma Lipoprotein-Associated Phospholipase A2 (PLA2G7 V297F Null Mutation) and Risk of Alzheimer's Disease in Japan.

06:00 EDT 17th July 2010 | BioPortfolio

Summary of "Genetic Deficiency of Plasma Lipoprotein-Associated Phospholipase A2 (PLA2G7 V297F Null Mutation) and Risk of Alzheimer's Disease in Japan."

High plasma lipoprotein phospholipase A2 activity (Lp-PLA2) was reported to be a risk factor for dementia. A loss of function polymorphism in the Lp-PLA2 gene - PLA2G7 V279F - is found almost exclusively in Asians. In 1,952 subjects with late-onset AD and 2,079 non-demented controls recruited from Japan, the PLA2G7 null allele was not associated with risk or age at onset of
AD:
logistic regression OR 0.98 (95% CI 0.86-1.12, p=0.81) per additional null allele, adjusted for age/age at onset, gender, and APOE epsilon4. Genetic deficiency of Lp-PLA2 activity is not associated with a reduced risk of AD in the Japanese population.

Affiliation

Genetics, GlaxoSmithKline, Research Triangle Park, NC, USA.

Journal Details

This article was published in the following journal.

Name: Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Pages:

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