Trans-Resveratrol Downregulates Txnip Overexpression Occurring During Liver Ischemia-Reperfusion.
Summary of "Trans-Resveratrol Downregulates Txnip Overexpression Occurring During Liver Ischemia-Reperfusion."
Txnip (thioredoxin-interacting protein) is a protein with multifunctional roles in cellular responses and stress-related diseases. Txnip is involved in intracellular redox regulation and has been recently described as a possible link between redox state and metabolism. trans-Resveratrol (T-res) is a natural phytoalexin with antiproliferative, antiapoptotic and antioxidative effects. However, to date there have been no reports of the implication of Txnip in a model of liver acute stress such as ischemia-reperfusion (I/R) and no work has looked for a T-res effect on Txnip. Here we studied the effects of a post-ischemic treatment of T-res on the liver thioredoxin (Trx)/ Txnip system and investigated whether the T-res effects were dependent on (*)NO production. In this work, liver I/R induced hepatic Txnip expression and T-res inhibited I/R Txnip expression. This decrease in Txnip expression by T-res was associated with an increase in liver Trx redox activity and a decrease in hepatic I/R-induced Trx-1 expression with no effect on Trx-2, on plasma Trx redox activity or on liver and plasma Trx reductase activity, independently of (*)NO production. In conclusion, these results show that in our model, not only did T-res protect Trx redox activity by diminishing the Txnip protein expression; it also reduced secretion of Trx1. This is the first report of a major implication of the Trx1/Txnip system in hepatic I/R injuries. It also affirms the importance of the antioxidant effect of T-res on the Trx1/Txnip system.
Affiliation
Equipe d'accueil 4466 Faculté de Pharmacie, Université Paris Descartes, Paris, France; Service de Biochimie, Hôpital Charles-Foix, AP-HP, France.
Journal Details
This article was published in the following journal.
Name: Biochimie
ISSN: 1638-6183
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20709139
- DOI: http://dx.doi.org/10.1016/j.biochi.2010.07.018
Medical and Biotech [MESH] Definitions
Trans-splicing
The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
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Farnesyltranstransferase
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Gene Products, Vpr
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Trans Fatty Acids
UNSATURATED FATTY ACIDS that contain at least one double bond in the trans configuration, which results in a greater bond angle than the cis configuration. This results in a more extended fatty acid chain similar to SATURATED FATTY ACIDS, with closer packing and reduced fluidity. HYDROGENATION of unsaturated fatty acids increases the trans content.
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