PDE5-Is for the Treatment of Concomitant ED and LUTS/BPH.
Summary of "PDE5-Is for the Treatment of Concomitant ED and LUTS/BPH."
Epidemiologic data in adult men exhibit a strong relationship between erectile dysfunction (ED) and lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH), indicating that men affected by ED should also be investigated for LUTS/BPH and those presenting with storage or voiding LUTS should be investigated for co-morbid ED. Common pathophysiolgical mechanisms underlying both LUTS/BPH and ED, including alteration of NO/cGMP or RhoA/Rho-kinase signaling and/or vascular or neurogenic dysfunction, are potential targets for proposed phosphodiesterase type 5 inhibitors (PDE5-Is). Several randomized controlled trials and only a few reviews including all commercially available PDE5-Is demonstrated the safety and efficacy of these drugs in the improvement of erectile function and urinary symptoms, in patients affected either by ED, LUTS, or both conditions.
Department of Urology, University of Florence, Careggi Hospital, Viale Pieraccini 18, 50139 Florence, Italy.
This article was published in the following journal.
Name: Current bladder dysfunction reports
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/23888186
- DOI: http://dx.doi.org/10.1007/s11884-013-0184-9
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