Metabolic Syndrome and the Functional Outcomes of Hip and Knee Arthroplasty.
Summary of "Metabolic Syndrome and the Functional Outcomes of Hip and Knee Arthroplasty."
Patients with an elevated systemic inflammatory state are known to report greater pain with knee osteoarthritis (OA). We investigated the influence of risk factors of metabolic syndrome (MetS) on patient function before and after hip and knee replacement surgery.
A total of 677 consecutive patients with primary knee replacement and 547 consecutive patients with primary hip replacement with at least one MetS risk factor were reviewed from our joint registry. Demographic variables of age, sex, and comorbidity were retrieved. MetS risk factors were defined as body mass index (BMI) > 30 kg/m(2), diabetes, hypertension, and hypercholesterolemia. Baseline and 1-year Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores were compared across patients by number of MetS risk factors, ranging from 1 to 4. Linear regression modeling was used to evaluate the effects of the MetS risk groups and the individual metabolic abnormalities on predicting baseline and 1-year WOMAC scores. Knee and hip patients were reviewed separately.
The knee and hip patients showed a significant difference in sex distribution, BMI, and mean comorbidity across risk groups (p < 0.05). Unadjusted analysis showed that baseline and 1-year WOMAC scores, for both knee and hip patients, increased significantly with increasing number of MetS risk factors (p < 0.05). The linear regression model with the individual metabolic abnormalities was found to be more predictive of outcome than one with the number of MetS risk factors. Hypertension and obesity were the metabolic factors most predictive of a poorer outcome following hip surgery as compared to just obesity for knee patients.
Patient function following joint replacement surgery, particularly hip surgery, is negatively affected by metabolic abnormalities perhaps secondary to the systemic proinflammatory state. This knowledge should be used when counseling patients prior to surgery.
From the Division of Orthopedic Surgery, University of Toronto, Toronto; and the Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
This article was published in the following journal.
Name: The Journal of rheumatology
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20634242
- DOI: http://dx.doi.org/10.3899/jrheum.091242
The purpose of this study was to compare 50 bicompartmental knee arthroplasty (BKA) and total knee arthroplasty (TKA) cases, particularly in restoring knee function. Patients were between 30 and 65yea...
A precept of a successful total knee arthroplasty (TKA) would be a well balanced, stable knee. We analyzed the effects of medial-lateral (ML) stability on functional outcome at 2years post-operatively...
The arthroplasty registries report the survivorship of knee arthroplasties and the reasons for revisions. The various registries report similar implant survivorships. However, the reasons for the knee...
Periprosthetic knee fractures and their complications are expected to increase as the numbers of knee arthroplasties continue to rise. We report our experience with revision knee arthroplasty for fail...
The incidence of total knee arthroplasty in young patients continues to rise in certain countries despite evidence of decreased patient satisfaction and increased likelihood for revision in patients 5...
A functional outcomes comparison study of three surgical techniques using minimally invasive surgery mini-incision (MIS) for total knee arthroplasty (TKA), standard para-patellar TKA and t...
The purpose of this study is to obtain patient oriented and clinically oriented physical function outcomes both pre-operatively and post-operatively in patients receiving a total knee arth...
Computer Aided Surgery in total knee arthroplasty improves knee stability and functional outcomes more than conventional total knee arthroplasty.
The purpose of the current study is to analyze and compare the lower-limb joint motions and muscle activation patterns during activities of daily living as well as self reported health rel...
The objective of this study is to document the demographic and clinical characteristics and the long-term clinical outcomes of patients who require a total knee arthroplasty (TKA). The hy...
Medical and Biotech [MESH] Definitions
Replacement of the knee joint.
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Injuries to the knee or the knee joint.
Replacement for a knee joint.
A SYNOVIAL CYST located in the back of the knee, in the popliteal space arising from the semimembranous bursa or the knee joint.