Once- vs Twice-Daily Budesonide/Formoterol in 6- to 15-Year-Old Patients With Stable Asthma.
Summary of "Once- vs Twice-Daily Budesonide/Formoterol in 6- to 15-Year-Old Patients With Stable Asthma."
Objective: To assess efficacy/tolerability of once-daily budesonide/formoterol pressurized metered-dose inhaler (pMDI) versus budesonide pMDI (primary) and twice-daily budesonide/formoterol (secondary) in children/adolescents with asthma stabilized with twice-daily budesonide/formoterol. Methods: This 12-week multicenter, double-blind randomized controlled study (www.clinicaltrials.gov identifier NCT00646321) included 521 patients aged 6 to 15 years with mild/moderate persistent asthma. Patients stabilized during a 4- to 5-week run-in with twice-daily budesonide/formoterol pMDI 40/4.5 mug x 2 inhalations (160/18 mug daily) received twice-daily budesonide/formoterol pMDI 40/4.5 mug x 2 inhalations (160/18 mug daily), once-daily budesonide/formoterol pMDI 80/4.5 mug x 2 inhalations (160/9 mug daily; evening), or once-daily budesonide pMDI 80 mug x 2 inhalations (160 mug daily; evening). Results: Once- or twice-daily budesonide/formoterol was more effective than budesonide for evening peak expiratory flow (primary variable) at the end of the 24-hour once-daily dosing interval (P
Affiliation
aPediatric Pulmonary Medicine, Childhood Asthma Care and Education Center, and Cystic Fibrosis Center, Louisville, Kentucky;
Journal Details
This article was published in the following journal.
Name: Pediatrics
ISSN: 1098-4275
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20713475
- DOI: http://dx.doi.org/10.1542/peds.2009-2970
Medical and Biotech [MESH] Definitions
Morbidity
The proportion of patients with a particular disease during a given year per given unit of population.
Budesonide
A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.
Seasonal Affective Disorder
A syndrome characterized by depressions that recur annually at the same time each year, usually during the winter months. Other symptoms include anxiety, irritability, decreased energy, increased appetite (carbohydrate cravings), increased duration of sleep, and weight gain. SAD (seasonal affective disorder) can be treated by daily exposure to bright artificial lights (PHOTOTHERAPY), during the season of recurrence.
Tourette Syndrome
A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a general medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
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El Nino-Southern Oscillation or ENSO is a cycle of extreme alternating warm El Niño and cold La Nina events which is the dominant year-to-year climate pattern on Earth. Both terms refer to large-scale changes in sea-surface temperature across the eastern tropical Pacific. ENSO is associated with a heightened risk of certain vector-borne diseases. (From http://www.elnino.noaa.gov/lanina_new_faq.html, accessed 5/12/2020)
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