Biological Importance and Statistical Significance.

08:00 EDT 2nd August 2013 | BioPortfolio

Summary of "Biological Importance and Statistical Significance."

Statistical ideas behind the analysis of experiments related to crop composition and the genetic factors underlying composition are discussed. The emphasis is on concepts rather than statistical formulations. Statistical analysis and biological considerations are shown to be complementary rather than contradictory, in that the statistical analysis of a dataset depends on the experimental design, that no amount of statistical sophistication can rescue a badly designed study, and good experimental design is crucial. The traditional null hypothesis significance testing approach has severe limitations but p values and statistical significance still often seem to be the primary objective of an analysis. Emphasis instead should be on identifying the size of effects that are biologically important and, with the involvement of the "domain" scientist, using these to help design experiments with appropriate sample sizes and statistical power. The issues discussed here are also directly applicable to other areas of research.


Journal Details

This article was published in the following journal.

Name: Journal of agricultural and food chemistry
ISSN: 1520-5118


DeepDyve research library

PubMed Articles [15427 Associated PubMed Articles listed on BioPortfolio]

The questioned p value: clinical, practical and statistical significance.

The use of p-value and statistical significance have been questioned since the early 80s in the last century until today. Much has been discussed about it in the field of statistics and its applicatio...

Statistics Commentary Series: Commentary No. 20: Statistical Significance and Practical Importance.

Clinical significance in nursing research: A discussion and descriptive analysis.

It is widely understood that statistical significance should not be equated with clinical significance, but the topic of clinical significance has not received much attention in the nursing literature...

The minimal clinically important difference (MCID) raised the significance of outcome effects above the statistical level, with methodological implications for future studies.

To illustrate and discuss current and proposed new concepts of effect size quantification and significance, with a focus on statistical and clinical/subjective interpretation and supported by empirica...

Self-Contained Statistical Analysis of Gene Sets.

Microarrays are a powerful tool for studying differential gene expression. However, lists of many differentially expressed genes are often generated, and unraveling meaningful biological processes fro...

Clinical Trials [2406 Associated Clinical Trials listed on BioPortfolio]

Differential Clinical and Serologic Response in Psoriasis and Psoriatic Arthritis to Drug Treatment

Psoriasis is a multifactorial cutaneous disorders which affects about 100000 patients in Taiwan. Psoriatic arthritis is also present in about 20~30 percents. Many drugs have been shown to ...

Coping With High Grade Glioma

1. Purpose and Objective: To determine the feasibility and short- and long-term efficacy of an empirically-based CST intervention (Keefe et al.) with caregivers of patients with...

Study on the Biological Prediction Models of Radiation Pneumonitis

Radiation pneumonitis is the most common complication and the major dose-limiting toxicity associated with radiotherapy, which can cause poor quality of life or life-threatening symptoms a...

Behaviour After Exercise of Biological, Clinical and Metabolic Variables as From Different Temperatures and Times of Immersion Cold Water Application

Introduction: immersion cold water is a recuperative strategy commonly used, however, are not yet fully understood the real effects of this technique on specific conditions. Objective: To ...

Breast Cancer Associated Antibodies

To determine the ability of the Cimmunology process to lead to in vitro antibody production, the ability of the ELISA assays to detect any of those antibodies, and to establish the relatio...

Medical and Biotech [MESH] Definitions

Biological systems as affected by time. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.

A multidisciplinary field of research and practice studying the periodicity of biological systems and the application of principles of chronobiology to various therapeutic strategies. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.

Evaluation of the degree of acceptance for the immediate variables associated with a procedure or program designed to change behavior. This includes the social significance of the goals of treatment, the social appropriateness of the treatment procedures, and the social importance of the effects of treatments.

The use of statistical and mathematical methods to analyze biological observations and phenomena.

Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.

Quick Search

DeepDyve research library

Relevant Topic

Biological Therapy
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...