Human Leukocyte Antigen Alleles And Susceptibility To Psoriatic Arthritis.

05:49 EDT 19th September 2014 | BioPortfolio

Summary of "Human Leukocyte Antigen Alleles And Susceptibility To Psoriatic Arthritis."

Our purpose was to determine associations between HLA alleles and psoriatic arthritis (PsA).

Affiliation

Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada.

Journal Details

This article was published in the following journal.

Name: Human immunology
ISSN: 1879-1166
Pages:

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Medical and Biotech [MESH] Definitions

Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others.

DNA probes specific for the human leukocyte antigen genes, which represent the major histocompatibility determinants in humans. The four known loci are designated as A, B, C, and D. Specific antigens are identified by a locus notation and number, e.g., HLA-A11. The inheritance of certain HLA alleles is associated with increased risk for certain diseases (e.g., insulin-dependent diabetes mellitus).

A type of inflammatory arthritis associated with PSORIASIS, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated SPONDYLARTHROPATHY, and the absence of rheumatoid factor.

Human immune-response, D-related antigen encoded by the D locus on chromosome 6 and found on lymphoid cells. It is associated with RHEUMATOID ARTHRITIS and SCHIZOPHRENIA.

A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.

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