Treatment and Dosimetric Advantages Between Vmat, Imrt, and Helical Tomotherapy in Prostate Cancer.

12:43 EDT 30th October 2014 | BioPortfolio

Summary of "Treatment and Dosimetric Advantages Between Vmat, Imrt, and Helical Tomotherapy in Prostate Cancer."

We investigated the possible treatment and dosimetric advantage of volumetric modulated arc therapy (VMAT) over step-and-shoot intensity-modulated radiation therapy (step-and-hhoot IMRT) and helical tomotherapy (HT). Twelve prostate cancer patients undergoing VMAT to the prostate were included. Three treatment plans (VMAT, step-and-shoot IMRT, HT) were generated for each patient. The doses to clinical target volume and 95% of planning target volume were both >/=78 Gy. Target coverage, conformity index, dose to rectum/bladder, monitor units (MU), treatment time, equivalent uniform dose (EUD), normal tissue complication probability (NTCP) of targets, and rectum/bladder were compared between techniques. HT provided superior conformity and significantly less rectal volume exposed to 65 Gy and 40 Gy, as well as EUD/NTCP of rectum than step-and-shoot IMRT, whereas VMAT had a slight dosimetric advantage over step-and-shoot IMRT. Notably, significantly lower MUs were needed for VMAT (309.7 +/- 35.4) and step-and-shoot IMRT (336.1 +/- 16.8) than for HT (3368 +/- 638.7) (p < 0.001). The treatment time (minutes) was significantly shorter for VMAT (2.6 +/- 0.5) than step-and-shoot IMRT (3.8 +/- 0.3) and HT (3.8 +/- 0.6) (p < 0.001). Dose verification of VMAT using point dose and film dosimetry met the accepted criteria. VMAT and step-and-shoot IMRT have comparable dosimetry, but treatment efficiency is significantly higher for VMAT than for step-and-shoot IMRT and HT.

Affiliation

Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.

Journal Details

This article was published in the following journal.

Name: Medical dosimetry : official journal of the American Association of Medical Dosimetrists
ISSN: 1873-4022
Pages:

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