Long-term Exposure to Benzalkoniun Chloride Disinfectants Results in Change of Microbial Community Structure and Increased Antimicrobial Resistance.

19:34 EST 27th February 2015 | BioPortfolio

Summary of "Long-term Exposure to Benzalkoniun Chloride Disinfectants Results in Change of Microbial Community Structure and Increased Antimicrobial Resistance."

The effect of benzalkonium chlorides (BACs), a widely used class of quaternary ammonium disinfectants, on microbial community structure and antimicrobial resistance was investigated using three aerobic microbial communities: BACs-unexposed (DP, fed a mixture of dextrin/peptone), BACs-exposed (DPB, fed a mixture of dextrin/peptone and BACs) and BACs-enriched (B, fed only BACs). Long-term exposure to BACs reduced community diversity and resulted in the enrichment of BAC-resistant species, predominantly Pseudomonas species. Exposure of the two microbial communities to BACs significantly decreased their susceptibility to BACs as well as three clinically relevant antibiotics (penicillin G, tetracycline, ciprofloxacin). Increased resistance to BACs and penicillin G of the two BACs-exposed communities is predominantly attributed to degradation or transformation of these compounds, whereas resistance to tetracycline and ciprofloxacin is largely due to the activity of efflux pumps. Quantification of several key multidrug resistance genes showed a much higher number of copies of these genes in the DPB and B microbial communities compared to the DP community. Collectively, our findings indicate that exposure of a microbial community to BACs results in increased antibiotic resistance, which has important implications for both human and environmental health.


Journal Details

This article was published in the following journal.

Name: Environmental science & technology
ISSN: 1520-5851


PubMed Articles [29463 Associated PubMed Articles listed on BioPortfolio]

Visual long-term memory and change blindness: Different effects of pre- and post-change information on one-shot change detection using meaningless geometric objects.

To clarify the relationship between visual long-term memory (VLTM) and online visual processing, we investigated whether and how VLTM involuntarily affects the performance of a one-shot change detecti...

Aluminium chloride impairs long-term memory and downregulates cAMP-PKA-CREB signalling in rats.

Epidemiological investigations have indicated that aluminium (Al) is an important environmental neurotoxicant that may be involved in the aetiology of the cognitive dysfunction associated with neurode...

Long-Term Exposure to Ambient Air Pollution and Serum Leptin in Older Adults: Results From the MOBILIZE Boston Study.

Long-term exposure to traffic-related air pollution has been linked to increased risk of obesity and diabetes and may be associated with higher serum levels of the adipokine leptin, but this hypothesi...

Effects of Long-term Exposure to Hydrogen Sulfide on Human Red Blood Cells.

Hydrogen sulfide (H2S) exhibits both physiological and toxicological roles in the biological systems. Acute exposure to high levels of H2S is life threatening while long-term exposure to ambient level...

Effects of Contact Lens Solution Disinfectants against Filamentous Fungi.

To assess and compare the antifungal activity of polyhexamethylene biguanide (PHMB), thimerosal, cetylpyridinium chloride, and chlorhexidine, which are disinfectants used in multipurpose disinfectant ...

Clinical Trials [5861 Associated Clinical Trials listed on BioPortfolio]

Promoting Long Term Dietary Change to Reduce CVD Risk

To test the long-term effectiveness of a new behavioral strategy, taste-based goal setting, that relied on the role of taste and eating favorite high-fat foods in moderation to minimize fe...

A Study to Evaluate GSK1325760A - a Long-Term Extension Study

The primary objective of this study is to evaluate the safety of long-term administration of GSK1325760A in patients with PAH. The secondary objectives of this study are to evaluate long-...

Randomized Clinical Trial of an Exposure-based Cognitive Therapy for Depression

The purpose of this study is to investigate, if exposure-based cognitive therapy (EBCT) is at least as effective as the established cognitive-behavioral therapy and more effective in its l...

Long-Term Effects of HIV Exposure and Infection in Children

As new drugs and vaccines are developed to prevent HIV disease progression and prolong survival of HIV infected patients, the short-term safety and effectiveness of these treatments are ev...

Sanctura Muscarinic Receptor Antagonist Resists Transport (SMART) Trial

This study evaluates the penetration through the blood-brain-barrier of trospium chloride at plasma steady state (Day 10) in elderly subjects with overactive bladder symptoms. Trospium le...

Medical and Biotech [MESH] Definitions

Health insurance to provide full or partial coverage for long-term home care services or for long-term nursing care provided in a residential facility such as a nursing home.

A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.

Experiments designed to determine the potential toxic effects of a long-term exposure to a chemical or chemicals.

Persons who have experienced prolonged survival of HIV infection. This includes the full spectrum of untreated, HIV-infected long-term asymptomatics to those with AIDS who have survived due to successful treatment.

A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.

Search BioPortfolio:

Searches Linking to this Article