Track topics on Twitter Track topics that are important to you
Silver-impregnated contact lens (CL) storage cases aim to reduce microbial contamination of storage cases during use, however there are limited data on their effectiveness. This study evaluated early anti-microbial activity of silver-impregnated CL cases and silver release characteristics in-vitro.
Three silver-impregnated CL storage cases Microblock, i-clean(R) and Nano-case(R) were evaluated. The test organisms included the ISO14729 panel and 2 clinical isolates, Delftia acidovorans and Stenotrophomonas maltophilia. Each well of the case was challenged with 2mL of the organism in phosphate buffered saline at 10(3), 10(4), 10(5) and 10(6) CFU/mL. Survivors were recovered following 6, 10 and 24h incubation at 25 degrees C. Inductively-coupled plasma mass spectrometry was used to quantify the release of silver from the cases for similar incubation conditions and for time points up to 28 days.
Significant differences in anti-microbial activity were observed between cases (p=0.001). Activity was only apparent after 24h. Microblock showed the highest activity against P. aeruginosa (2.4+/-0.5 log reduction at 10(6)), S. marcescens (3.3+/-0.9 log reduction), D. acidovorans (2.8+/-0.1 log reduction) and F. solani (0.5+/-0.2). i-clean(R) was most effective against S. aureus (5.4+/-1.1 log reduction), whereas Nano-case(R) showed the greatest activity against S. maltophilia (0.2+/-0.3 log reduction). Microblock was the only case to demonstrate the silver release over 28 days.
Current silver-impregnated CL storage cases show variation in their in vitro antimicrobial activity. Broadly, the Microblock case demonstrated robust activity against most Gram-negative bacteria, while the i-clean(R) case was more effective against S. aureus. Silver release data suggest different modes of action for different cases.
University of New South Wales, Brien Holden Vision Institute, School of Optometry and Vision Science, Sydney, Australia.
This article was published in the following journal.
Name: Investigative ophthalmology & visual science
To evaluate contact lens (CL) storage case contamination when used with four different CL care solutions during daily wear of three different CL materials.
To determine whether variations in multipurpose disinfecting solution (MPDS) storage osmolarity from inappropriate contact lens (CL) case cleaning affect ocular surface integrity and wearer comfort.
The aim of this study was to measure the changes in the bacterial bioburden in orthokeratology (OK) lens storage cases using the DNA dot hybridization assay (DHA) after forewarning patients about thei...
Compliance with practitioner recommended lens care guidelines was assessed and compared in two test groups: patients belonging to a subscription membership group and a nonaffiliated group of 2-week fr...
Studies indicate that contact lens (CL) discontinuation mostly occurs because of dryness and discomfort symptoms. This study aimed to investigate relationships between changes in the concentration of ...
Contact lens induced dry eyes leads to lens intolerance and discontinuation. Incidence of dry eye in contact lens wearer is significantly higher in Asian population compared to other ethni...
The purpose of this trial is to evaluate the factors affecting comfortable contact lens wear and how those factors affect contact lens replacement frequency.
Three arm study comparing three novel contact lens solutions.
The purpose of this study is to compare visual acuity and redness of eyes between a new contact lens and an already marketed contact lens.
This is a pilot evaluation to assess the feasibility of using novel imaging process to characterize lens edge and limbal epithelial thickness profile; lens movement with gaze and blink; an...
Sterile collagen strands obtained from healthy mammals. They are used as absorbable surgical ligatures and are frequently impregnated with chromium or silver for increased strength. They tend to cause tissue reaction.
The use of silver, usually silver nitrate, as a reagent for producing contrast or coloration in tissue specimens.
Sterile solutions used to clean and disinfect contact lenses.
Insertion of an artificial lens to replace the natural CRYSTALLINE LENS after CATARACT EXTRACTION or to supplement the natural lens which is left in place.
Silver. An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.
Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells. In vertebrates, it is composed of blo...