The influence of human immunodeficiency virus and CD4 count on the prevalence of human papillomavirus in heterosexual couples.
Summary of "The influence of human immunodeficiency virus and CD4 count on the prevalence of human papillomavirus in heterosexual couples."
This study investigated the impact of human immunodeficiency virus (HIV) infection on genital human papillomavirus (HPV) in heterosexual couples. More HIV-positive men and women had genital HPV compared to HIV-negative men (77% vs 49%; P<0.001) and women (74% vs 36%; P<0.001). More men and women with partners that were HPV positive had HPV genital infection compared to those with HPV negative partners (for men 72% compared to 40%, P<0.001). Men with HIV-positive female partners were at greater risk of high-risk HPV (HR-HPV) and low-risk HPV (LR-HPV) infection compared to men with HIV-negative female partners and risk increased with decreasing CD4+ count (> or equal to 350m
L:
OR, 2.37 [95%
CI:
1.1.47-3.83]; <350m
L:
OR, 3.02 [95%
CI:
1.86-4.9]). Conversely, the risk of any HPV type was not found to differ between women with a HIV-positive or HIV-negative male partner. In men, HIV infection and female partner HIV-positive status were both associated with a higher risk of type-specific HPV concordance with their sexual partner, though the associations were not significant for LR-HPV. In women, HIV infection and low CD4 count were significantly associated with increased risk of type-specific HPV concordance, but male partner HIV-positive status was not significantly associated with this concordance. In conclusion, male genital HPV prevalence and type-specific sharing was influenced by their own HIV-positive status and that of their female partner. In contrast, female genital HPV prevalence and HPV type-specific sharing was determined by their own HIV-positive status and not by that of their male partner.
Affiliation
University of Cape Town;
Journal Details
This article was published in the following journal.
Name: The Journal of general virology
ISSN: 1465-2099
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20719990
- DOI: http://dx.doi.org/10.1099/vir.0.020669-0
Medical and Biotech [MESH] Definitions
Vpr Gene Products, Human Immunodeficiency Virus
Proteins encoded by the VPR GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
Nef Gene Products, Human Immunodeficiency Virus
Proteins encoded by the NEF GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
Vif Gene Products, Human Immunodeficiency Virus
Proteins encoded by the VIF GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
Tat Gene Products, Human Immunodeficiency Virus
Proteins encoded by the TAT GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
Rev Gene Products, Human Immunodeficiency Virus
Proteins encoded by the REV GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
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