Unexpected interaction between quetiapine and valproate in patients with bipolar disorder.
Summary of "Unexpected interaction between quetiapine and valproate in patients with bipolar disorder."
Quetiapine, a second-generation antipsychotic originally used in the treatment of schizophrenia, was also found to be effective as monotherapy or as an adjunctive therapy for acute mania. Delirium in patients treated with quetiapine seems to be a rare phenomenon; however, we report two patients with bipolar disorder who developed delirium when prescribed quetiapine as an adjunct to valproate for acute mania. Both had previously developed mild renal insufficiency after an episode of lithium intoxication. The delirium resolved after quetiapine was discontinued. Unexpected interactions may occur when medications are combined without being subject to controlled clinical trials.
Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan; Department of Psychiatry and Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.
This article was published in the following journal.
Name: General hospital psychiatry
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20633751
- DOI: http://dx.doi.org/10.1016/j.genhosppsych.2009.06.005
Medical and Biotech [MESH] Definitions
Retinal Bipolar Cells
INTERNEURONS of the vertebrate RETINA containing two processes. They receive inputs from the RETINAL PHOTORECEPTOR CELLS and send outputs to the RETINAL GANGLION CELLS. The bipolar cells also make lateral connections in the retina with the RETINAL HORIZONTAL CELLS and with the AMACRINE CELLS.
Protein Interaction Mapping
Methods for determining interaction between proteins.
Reciprocal action of two vertebrate photoreceptor cells (RODS AND CONES). Rod-cone interaction occurs during MESOPIC VISION in which both rods and cones are active in light transduction to the VISUAL CORTEX. Such interaction can influence visual sensitivity and luminous efficiency.
A complex involuntary response to an unexpected strong stimulus usually auditory in nature.
Efforts and designs to reduce the incidence of unexpected undesirable events in various environments and situations.
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