Prognostic significance of high grade dysplasia in colorectal adenomas.

12:16 EDT 30th March 2015 | BioPortfolio

Summary of "Prognostic significance of high grade dysplasia in colorectal adenomas."

Method A search of patients who had had endoscopic removal of an high grade adenoma was carried out. Patients with the following were excluded: follow-up of less than 1 year, polyposis syndromes, prior colon cancer, and a diagnosis of adenocarcinoma within 6 months following initial diagnosis. Results: 83 patients treated between 1999-2007 for high-grade dysplasia in a colorectal adenoma were identified. Over a median follow up period of 4 years, 53 (64%) developed further adenomatous polyps. Among these, 7% has an adenoma with high-grade dysplasia or an adenocarcinoma. In all these cases the initial high grade adenoma was >1 cm in diameter. Initial follow-up colonoscopy was performed on average 7 months following the initial diagnosis. 10% of patients underwent prophylactic segmental resection and 6% received argon laser therapy. Conclusion: The study demonstrates that patients who have a colorectal adenoma > 1 cm with high-grade dysplasia may be at high risk of developing further adenomas with high- grade dysplasia or carcinoma. Close follow up is warranted.


Pathology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

Journal Details

This article was published in the following journal.

Name: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
ISSN: 1463-1318


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