Atypical molecular profile for joint development in the avian costal joint.
Summary of "Atypical molecular profile for joint development in the avian costal joint."
Development of synovial joints involves generation of cartilaginous anlagen, formation of interzones between cartilage anlagen, and cavitation of interzones to produce fluid filled cavities. Interzone development is not fully understood, but interzones are thought to develop from skeletogenic cells that are inhibited from further chondrogenic development by a cascade of gene expression including Wnt and Bmp family members. We examined the development of the rarely studied avian costal joint to better understand mechanisms of joint development. The costal joint is found within ribs, is morphologically similar to the metatarsophalangeal joint, and undergoes cavitation in a similar manner. In contrast to other interzones, Wnt14/9a, Gdf5, Chordin, Barx1, and Bapx1 are absent from the costal joint interzone, consistent with the absence of active beta-catenin and phosphorylated Smad 1/5/8. However Autotaxin and Noggin are expressed. The molecular profile of the costal joint suggests there are alternative mechanisms of interzone development. Developmental Dynamics, 2010. (c) 2010 Wiley-Liss, Inc.
Affiliation
Wesleyan University, Biology Department, Middletown, Connecticut.
Journal Details
This article was published in the following journal.
Name: Developmental dynamics : an official publication of the American Association of Anatomists
ISSN: 1097-0177
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20730871
- DOI: http://dx.doi.org/10.1002/dvdy.22388
Medical and Biotech [MESH] Definitions
Joint Capsule Release
Surgical procedure to relax the JOINT CAPSULE tissues in a joint that has a reduced range of motion due to CONTRACTURE or TISSUE ADHESIONS or joint deformities.
Joint Instability
Lack of stability of a joint or joint prosthesis. Factors involved are intra-articular disease and integrity of extra-articular structures such as joint capsule, ligaments, and muscles.
Hand Joints
The articulations extending from the WRIST distally to the FINGERS. These include the WRIST JOINT; CARPAL JOINTS; METACARPOPHALANGEAL JOINT; and FINGER JOINT.
Foot Joints
The articulations extending from the ANKLE distally to the TOES. These include the ANKLE JOINT; TARSAL JOINTS; METATARSOPHALANGEAL JOINT; and TOE JOINT.
Wrist Joint
The joint that is formed by the distal end of the RADIUS, the articular disc of the distal radioulnar joint, and the proximal row of CARPAL BONES; (SCAPHOID BONE; LUNATE BONE; triquetral bone).
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