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The mechanisms by which Nuclear Hormone Receptors (NHRs) regulate transcription are highly dynamic and require interplay between a myriad of regulatory protein complexes including the 26S proteasome. Protein degradation is the most well-established role of the proteasome; however, an increasing body of evidence suggests that the 26S proteasome may regulate transcription in proteolytic and non-proteolytic mechanisms. Here we review how these mechanisms may apply to NHR-mediated transcriptional regulation.
This article was published in the following journal.
Name: Biochimica et biophysica acta
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