Magnetophoresis for enhancing transdermal drug delivery: Mechanistic studies and patch design.
Summary of "Magnetophoresis for enhancing transdermal drug delivery: Mechanistic studies and patch design."
Magnetophoresis is a method of enhancement of drug permeation across biological barriers by the application of magnetic field. The present study investigated the mechanistic aspects of magnetophoretic transdermal drug delivery and also assessed the feasibility of designing a magnetophoretic transdermal patch system for the delivery of lidocaine. In Vitro drug permeation studies were carried out across the porcine epidermis at different magnetic field strengths. The magnetophoretic drug permeation "flux enhancement factor" was found to increase with the applied magnetic field strength. The mechanistic studies revealed that the magnetic field applied in this study did not modulate permeability of the stratum corneum barrier. The predominant mechanism responsible for magnetically mediated drug permeation enhancement was found to be "magnetokinesis". The octanol/water partition coefficient of drugs was also found to increase when exposed to the magnetic field. A reservoir type transdermal patch system with a magnetic backing was designed for in vivo studies. The dermal bioavailability (AUC(0-6h)) from the magnetophoretic patch system in vivo, in rats was significantly higher than the similarly designed non-magnetic control patch.
Department of Pharmaceutics, The University of Mississippi, University, MS 38677.
This article was published in the following journal.
Name: Journal of controlled release : official journal of the Controlled Release Society
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20728484
- DOI: http://dx.doi.org/10.1016/j.jconrel.2010.08.015
Abstract Today, ∼74% of drugs are taken orally and are not found to be as effective as desired. To improve such characteristics, transdermal drug delivery was brought to existence. This delivery sys...
Aim: To uptake and release hydrophilic model drugs and insulin in a novel conductive polymer (CP) nanotube transdermal patch. Materials & methods: The externally controlled transdermal delivery of mod...
Transdermal drug delivery systems are topically administered medicaments in the form of patches that deliver drugs for systemic effects at a predetermined and controlled rate. It works very simply in...
Iontophoresis is now established as one of the methods of enhancing transdermal delivery of drugs. However, its ability to enhance the delivery of highly lipophilic compounds is poor due to lack of an...
It has recently been proposed that the combination of skin barrier impairment using microneedles (MNs) coupled with iontophoresis (ITP) may broaden the range of drugs suitable for transdermal delivery...
A multi-center study to evaluate the efficacy of CHADD (Controlled Heat-Assisted Drug Delivery) applied over a 50 mcg/hr ZR-02-01 matrix transdermal fentanyl patch for the treatment of bre...
The purpose of the study is to evaluate the safety and effectiveness of the investigational ketoprofen patch with a controlled heating patch, compared to placebo (inactive substance) for t...
This study will use two doses of rivastigmine transdermal patch (5cm2, 10cm2) to establish the feasibility of 2 switch schedules (with transdermal patch one-step dose titration or without...
Tohe purpose of this study is to demonstrate the bioequivalence of a fentanyl patch transdermal delivery system.
The purpose of this study is to examine the the efficacy of adjunctive nicotine replacement therapy when used in combination with the contingency management (CM) + cognitive behavioral the...
Medical and Biotech [MESH] Definitions
A medicated adhesive patch placed on the skin to deliver a specific dose of medication into the bloodstream.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
The action of a drug in promoting or enhancing the effectiveness of another drug.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
The utilization of drugs as reported in individual hospital studies, FDA studies, marketing, or consumption, etc. This includes drug stockpiling, and patient drug profiles.