Second to fourth digit ratio: a predictor of prostate-specific antigen level and the presence of prostate cancer.
Summary of "Second to fourth digit ratio: a predictor of prostate-specific antigen level and the presence of prostate cancer."
Study Type - Diagnostic (exploratory cohort) Level of Evidence 2b OBJECTIVE To investigate the relationships between the 2nd to 4th digit ratio (digit ratio) and prostate volume, prostate-specific antigen (PSA) level, and the presence of prostate cancer. PATIENTS AND METHODS Of the men that presented with lower urinary tract symptoms (LUTS) at a single tertiary academic center, 366 men aged 40 or older with a PSA level =40 ng/mL were prospectively enrolled. Right-hand 2nd and 4th digit lengths were measured prior to the PSA determinations and transrectal ultrasonography (TRUS). Prostate volumes were measured by TRUS without information about digit length. Patients with a PSA level >/=3 ng/mL underwent prostate biopsy. RESULTS No relationship was found between prostate volume and digit ratio [correlation coefficient (r) =-0.038, P= 0.466]. But, significant negative correlations were found between digit ratio and PSA (r=-0.140, P= 0.007). When the patients were divided into two groups (Group
digit ratio <0.95, n= 184; Group
digit ratio >/=0.95, n= 182), Group A had a higher mean PSA level than Group B (3.26 +/- 5.54 ng/mL vs 1.89 +/- 2.24 ng/mL, P= 0.002) and had significantly higher risks of prostate biopsy [odds ratio (OR) = 1.75, 95% CI = 1.07-2.84] and prostate cancer (OR = 3.22, 95% CI = 1.33-7.78). CONCLUSIONS Patients with a lower digit ratio have higher risks of prostate biopsy and prostate cancer.
Department of Urology, Gachon University Gil Hospital, Incheon, Korea.
This article was published in the following journal.
Name: BJU international
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20633006
- DOI: http://dx.doi.org/10.1111/j.1464-410X.2010.09490.x
Medical and Biotech [MESH] Definitions
Prostatic Secretory Proteins
Proteins secreted by the prostate gland. The major secretory proteins from the human prostate gland include PROSTATE-SPECIFIC ANTIGEN, prostate-specific acid phosphatase, prostate-specific membrane antigen, and prostate-specific protein-94.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
Seminal Plasma Proteins
Proteins found in SEMEN. Major seminal plasma proteins are secretory proteins from the male sex accessory glands, such as the SEMINAL VESICLES and the PROSTATE. They include the seminal vesicle-specific antigen, an ejaculate clotting protein; and the PROSTATE-SPECIFIC ANTIGEN, a protease and an esterase.
Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.
A family of trypsin-like SERINE ENDOPEPTIDASES that are expressed in a variety of cell types including human prostate epithelial cells. They are formed from tissue prokallikrein by action with TRYPSIN. They are highly similar to PROSTATE-SPECIFIC ANTIGEN. EC 126.96.36.199.
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