The relationship between occupational exposure to lead and manifestation of cardiovascular complications in persons with arterial hypertension.
Summary of "The relationship between occupational exposure to lead and manifestation of cardiovascular complications in persons with arterial hypertension."
The chronic exposure to lead represents a risk factor of arterial hypertension development. Ambulatory blood pressure monitoring is the most prognostically reliable method of measuring of arterial blood pressure. The study is aimed at evaluation of a relationship between occupational exposure to lead and manifestation of cardiovascular complications in patients with arterial hypertension. The studies included 73 men (mean age: 54.26+/-8.17years) with arterial hypertension, treated with hypotensive drugs: group I - persons occupationally exposed to lead (n=35), and group II - individuals not exposed to lead (n=38). An analysis of results obtained during ambulatory blood pressure monitoring disclosed significantly higher mean values of mean systolic blood pressure, mean blood pressure, pulse pressure and variability of systolic blood pressure in the group of hypertensive patients occupationally exposed to lead as compared to patients with arterial hypertension but not exposed to lead. The logistic regression showed that a more advanced age, higher concentration of blood zinc protoporphyrin, and a higher mean value of pulse pressure represented independent risk factors of left ventricular hypertrophy in the group of persons affected by arterial hypertension and chronically exposed to lead (OR(age)=1.11; OR(ZnPP)=1.32; OR(PP) = 1,45; p<0.05). In view of the above data demonstration that occupational exposure to lead represents an independent risk factor of increased pulse pressure may be of key importance in the process of shaping general social awareness as to harmful effects of lead compounds on human health.
Affiliation
Department of Internal Medicine and Hypertension, Wroclaw Medical University, Pasteur 4, PL 50-367 Wrocław, Poland.
Journal Details
This article was published in the following journal.
Name: Toxicology and applied pharmacology
ISSN: 1096-0333
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20728461
- DOI: http://dx.doi.org/10.1016/j.taap.2010.08.012
Medical and Biotech [MESH] Definitions
Lead Poisoning, Nervous System, Childhood
Neurologic disorders occurring in children following lead exposure. The most frequent manifestation of childhood lead toxicity is an encephalopathy associated with chronic ingestion of lead that usually presents between the ages of 1 and 3 years. Clinical manifestations include behavioral changes followed by lethargy; CONVULSIONS; HALLUCINATIONS; DELIRIUM; ATAXIA; and vomiting. Elevated intracranial pressure (HYPERTENSION, INTRACRANIAL) and CEREBRAL EDEMA may occur. (From Adams et al., Principles of Neurology, 6th ed, p1210-2)
Lead Poisoning, Nervous System
Injury to the nervous system secondary to exposure to lead compounds. Two distinct clinical patterns occur in children (LEAD POISONING, NERVOUS SYSTEM, CHILDHOOD) and adults (LEAD POISONING, NERVOUS SYSTEM, ADULT). In children, lead poisoning typically produces an encephalopathy. In adults, exposure to toxic levels of lead is associated with a peripheral neuropathy.
Pregnancy Complications, Cardiovascular
The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.
Lead Poisoning, Nervous System, Adult
Neurologic conditions in adults associated with acute or chronic exposure to lead or any of its salts. The most common lead related neurologic syndrome in adults consists of a polyneuropathy involving motor fibers. This tends to affect distal nerves and may present as wrist drop due to RADIAL NEUROPATHY. Additional features of chronic lead exposure include ANEMIA; CONSTIPATION; colicky abdominal pain; a bluish lead line of the gums; interstitial nephritis (NEPHRITIS, INTERSTITIAL); and saturnine gout. An encephalopathy may rarely occur. (From Adams et al., Principles of Neurology, 6th ed, p1212)
Occupational Exposure
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
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