Abdominal Visceral Adipose Tissue Volume is Associated with Increased Risk of Erosive Esophagitis in Men and Women.
Summary of "Abdominal Visceral Adipose Tissue Volume is Associated with Increased Risk of Erosive Esophagitis in Men and Women."
BACKGROUND &
AIMS:
: Data on the association between erosive esophagitis and obesity are inconsistent because of variations in study populations and methods used to determine obesity.
METHODS:
: Participants in a prospective health screening cohort underwent esophagogastroduodenoscopy and computed tomography. The association between erosive esophagitis and obesity (measured by body mass index [BMI], waist circumference, and abdominal visceral adipose tissue volume) was estimated with odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for confounding factors. We also analyzed the association between obesity and erosive esophagitis by sex.
RESULTS:
: The prevalence of erosive esophagitis was 9.3% (495/5329). The OR for erosive esophagitis correlated with obesity measured by BMI, waist circumference, and abdominal visceral adipose tissue volume ( P < .001 for each factor). The multivariate OR for erosive esophagitis was 1.97 (95% CI, 1.34-2.90) for a visceral adipose tissue volume of 500-999 cm(3), 2.27 (95% CI, 1.51-3.39) for 1000-1499 cm(3), and 2.94 (95% CI, 1.87-4.62) for 1500 cm(3), compared with participants that had visceral adipose tissue volumes less than 500 cm(3). When measures of obesity were analyzed simultaneously, abdominal visceral adipose tissue volume, but not BMI or waist circumference, was associated with erosive esophagitis. The 3 measures of obesity were significantly associated with erosive esophagitis in men, but only visceral adipose tissue volume was associated with erosive esophagitis in women ( P = 0.002).
CONCLUSIONS:
: In contrast to BMI or waist circumference, abdominal visceral adipose tissue volume is associated with an increased risk of erosive esophagitis in men and women.
Affiliation
Center for Cancer Prevention & Detection, National Cancer Center, Goyang, Korea.
Journal Details
This article was published in the following journal.
Name: Gastroenterology
ISSN: 1528-0012
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20727886
- DOI: http://dx.doi.org/10.1053/j.gastro.2010.08.019
Medical and Biotech [MESH] Definitions
Intra-abdominal Fat
Fatty tissue inside the ABDOMINAL CAVITY, including visceral fat and retroperitoneal fat. It is the most metabolically active fat in the body and easily accessible for LIPOLYSIS. Increased visceral fat is associated with metabolic complications of OBESITY.
Adipose Tissue
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Neoplasms, Adipose Tissue
Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.
Adipose Tissue, White
Fatty tissue composed of WHITE ADIPOCYTES and generally found directly under the skin (SUBCUTANEOUS FAT) and around the internal organs (ABDOMINAL FAT). It has less vascularization and less coloration than the BROWN FAT. White fat provides heat insulation, mechanical cushion, and source of energy.
Peritoneum
A membrane of squamous EPITHELIAL CELLS, the mesothelial cells, covered by apical MICROVILLI that allow rapid absorption of fluid and particles in the PERITONEAL CAVITY. The peritoneum is divided into parietal and visceral components. The parietal peritoneum covers the inside of the ABDOMINAL WALL. The visceral peritoneum covers the intraperitoneal organs. The double-layered peritoneum forms the MESENTERY that suspends these organs from the abdominal wall.
PubMed Articles
Sugar-Sweetened and Diet Beverages in Relation to Visceral Adipose Tissue.
Frequent sugar-sweetened beverage (SSB) intake has been consistently associated with increased adiposity and cardio-metabolic risk, whereas the association with diet beverages is more mixed. We examin...
Visceral adipose tissue (VAT) is associated with abnormal cardiovascular and metabolic profiles. Total VAT volume of the abdominal compartment by MRI is the gold standard measurement for VAT but is co...
Summary The adipose tissue metabolism is dependent on its blood perfusion. During lipid mobilization e.g. during exercise and during lipid deposition e.g. postprandial, adipose tissue blood flow is in...
Epidemiological studies have demonstrated a strong link between increased visceral fat and metabolic syndrome. In rodents, removal of intra-abdominal but non-visceral fat improves insulin sensitivity...
AbstractObjective- Finding the anthropometric measure of visceral obesity is essential to clinical practice, because it predicts cardiovascular and metabolic risks. Sagittal abdominal diameter (SAD) h...
Clinical Trials
In type 2 diabetic patients with poor glycemic control despite maximum "classic" oral treatment, bed time insulin therapy may lead to a parallel increase in abdominal visceral and subcutan...
TH9507 in Patients With HIV-Associated Lipodystrophy
HIV lipodystrophy affects a significant proportion of patients treated with combination antiretroviral therapy (ART) and is characterized by excess visceral fat accumulation and loss of ex...
TH9507 in Patients With HIV-Associated Lipodystrophy
HIV lipodystrophy affects a significant proportion of patients treated with combination antiretroviral therapy (ART) and is characterized by excess visceral fat accumulation, loss of extre...
TH9507 Extension Study in Patients With HIV- Associated Lipodystrophy
HIV lipodystrophy affects a significant proportion of patients treated with combination antiretroviral therapy (ART) and is characterized by excess visceral fat accumulation, loss of extre...
Treatment of Abnormal Adipose Tissue Accumulation in HIV Patients
The primary objective of the study is to determine if Serostim® 4 mg administered daily for 12 weeks as treatment for the abnormal fat accumulation and distribution associated with HIV-as...
