Real-time contrast-enhanced ultrasound determination of microvascular blood volume in abdominal subcutaneous adipose tissue in man. Evidence for adipose tissue capillary recruitment.
Summary of "Real-time contrast-enhanced ultrasound determination of microvascular blood volume in abdominal subcutaneous adipose tissue in man. Evidence for adipose tissue capillary recruitment."
Summary The adipose tissue metabolism is dependent on its blood perfusion. During lipid mobilization e.g. during exercise and during lipid deposition e.g. postprandial, adipose tissue blood flow is increased. This increase in blood flow may involve capillary recruitment in the tissue. We investigated the basic and postprandial microvascular volume in adipose tissue using real-time contrast-enhanced ultrasound (CEU) imaging in healthy normal weight subjects. In nine subjects, CEU was performed in abdominal subcutaneous adipose tissue and in the underlying skeletal muscle after a bolus injection of ultrasound contrast agent to establish the reproducibility of the technique. In nine subjects, the effect of an oral glucose load on blood flow and microvascular volume was measured in abdominal subcutaneous adipose tissue and forearm skeletal muscle. (133)Xe washout and venous occlusion strain-gauge plethysmography was used to measure the adipose tissue and forearm blood flow, respectively. Ultrasound signal intensity of the first plateau phases was 27 +/- dB in the abdominal subcutaneous adipose tissue and 18 +/- 2dB (P<0.05) in the underlying skeletal muscle. The reproducibility of the measurements was good with a 4% coefficient of variation in both tissues. Blood flow and the change in signal intensity as a measure of the microvascular volume increased significantly and simultaneously in abdominal subcutaneous adipose tissue after glucose intake. The forearm blood flow and muscle signal intensity remained constant. It is concluded that the microvascular volume and changes in volume in abdominal subcutaneous adipose tissue can be assessed using CEU with good reproducibility. Postprandial capillary recruitment takes place in abdominal subcutaneous adipose tissue.
Affiliation
Department of Clinical Physiology and Nuclearmedicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen NV, Denmark.
Journal Details
This article was published in the following journal.
Name: Clinical physiology and functional imaging
ISSN: 1475-097X
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20731685
- DOI: http://dx.doi.org/10.1111/j.1475-097X.2010.00964.x
Medical and Biotech [MESH] Definitions
Ultrasonography, Doppler, Duplex
Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.
Blood Circulation Time
Determination of the shortest time interval between the injection of a substance in the vein and its arrival at some distant site in sufficient concentration to produce a recognizable end result. It represents approximately the inverse of the average velocity of blood flow between two points.
Contrast Media
Substances used to allow enhanced visualization of tissues.
Blood Volume Determination
Method for determining the circulating blood volume by introducing a known quantity of foreign substance into the blood and determining its concentration some minutes later when thorough mixing has occurred. From these two values the blood volume can be calculated by dividing the quantity of injected material by its concentration in the blood at the time of uniform mixing. Generally expressed as cubic centimeters or liters per kilogram of body weight.
Ultrasonography, Doppler
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
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