Long-term survival of a patient with leptomeningeal involvement by nasopharyngeal carcinoma after treatment with high-dose intravenous methotrexate.
Summary of "Long-term survival of a patient with leptomeningeal involvement by nasopharyngeal carcinoma after treatment with high-dose intravenous methotrexate."
BACKGROUND.: Nasopharyngeal carcinoma with leptomeningeal involvement is rare and typically has poor prognosis. METHODS AND RESULTS.: We present a case report of a patient with nasopharyngeal carcinoma who was treated with high-dose intravenous methotrexate and remains asymptomatic and without clinical evidence of disease 6 years later. CONCLUSIONS.: Systemic high-dose methotrexate should be evaluated in the treatment of advanced nasopharyngeal carcinoma with central nervous involvement. (c) 2010 Wiley Periodicals, Inc. Head Neck, 2010.
Affiliation
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Journal Details
This article was published in the following journal.
Name: Head & neck
ISSN: 1097-0347
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20737501
- DOI: http://dx.doi.org/10.1002/hed.21516
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