Hereditary predisposition rather than environmental factor are likely to explain the familial link between uveal melanoma and other cancers.
Summary of "Hereditary predisposition rather than environmental factor are likely to explain the familial link between uveal melanoma and other cancers."
No Summary Available
Affiliation
Department of Ophthalmology, The Ohio State University, 400 W 12th Ave, Rm 202, Columbus, OH, 43210, USA, Mohamed.abdel-rahman@osumc.edu.
Journal Details
This article was published in the following journal.
Name: Familial cancer
ISSN: 1573-7292
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20737292
- DOI: http://dx.doi.org/10.1007/s10689-010-9375-0
Medical and Biotech [MESH] Definitions
Neuroleukin
Neuronal growth factor and lymphokine product of lectin-stimulated T-cells which induces immunoglobulin secretion. Its amino acid sequence is partially homologous to the HIV envelope glycoprotein gp120, which may explain, in part, the pathogenesis of AIDS DEMENTIA COMPLEX. Closely related to PHOSPHOHEXOSE ISOMERASE; AUTOCRINE MOTILITY FACTOR and maturation factor.
Factor Xii
Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
Hereditary Angioedema Type Iii
A form of hereditary angioedema that occurs in women and is precipitated or worsened by high ESTROGEN levels. It is associated with mutations in the gene for FACTOR XII that result in its increased activity.
Biodegradation, Environmental
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
Factor Xi Deficiency
A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia.
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