SEVERE GENITAL ULCERATION IN AN ACUTE EPSTEIN-BARR VIRUS INFECTION.
Summary of "SEVERE GENITAL ULCERATION IN AN ACUTE EPSTEIN-BARR VIRUS INFECTION."
Genital ulceration is a rare manifestation of infectious mononucleosis caused by Epstein-Barr virus (EBV). We report a girl with severe genital ulceration and tissue necrosis during primary EBV infection that required surgical debridement. The excised genital tissue was EBV polymerase chain reaction-positive whereas in situ hybridization was negative. This suggests that the ulceration was likely because of the inflammatory response to the virus and not because of the intense viral infection of the genitalia.
From the *Department of Pathology and Laboratory Medicine, daggerDivision of Infectious Diseases; and Departments of double daggerPediatrics and section signGeneral Surgery, Children's and Women's Health Centre of British Columbia, Vancouver, BC, Canada.
This article was published in the following journal.
Name: The Pediatric infectious disease journal
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20736877
- DOI: http://dx.doi.org/10.1097/INF.0b013e3181f41b2e
Medical and Biotech [MESH] Definitions
A common, acute infection usually caused by the Epstein-Barr virus (HERPESVIRUS 4, HUMAN). There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis.
Epithelial hyperplasia of the oral mucosa associated with Epstein-Barr virus (HERPESVIRUS 4, HUMAN) and found almost exclusively in persons with HIV infection. The lesion consists of a white patch that is often corrugated or hairy.
Epstein-barr Virus Infections
Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).
A genus of the family HERPESVIRIDAE, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans and new world primates. The type species human herpesvirus 4 (HERPESVIRUS 4, HUMAN) is better known as the Epstein-Barr virus.
An angiocentric and angiodestructive lymphoproliferative disorder primarily involving the lungs. It is caused by an Epstein-Barr virus-induced transformation of the B-cells, in a T-cell rich environment. Clinically and pathologically it resembles EXTRANODAL NK-T-CELL LYMPHOMA.
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