New Approaches to Enhanced Remineralization of Tooth Enamel.

06:00 EDT 27th August 2010 | BioPortfolio

Summary of "New Approaches to Enhanced Remineralization of Tooth Enamel."

Dental caries is a highly prevalent diet-related disease and is a major public health problem. A goal of modern dentistry is to manage non-cavitated caries lesions non-invasively through remineralization in an attempt to prevent disease progression and improve aesthetics, strength, and function. Remineralization is defined as the process whereby calcium and phosphate ions are supplied from a source external to the tooth to promote ion deposition into crystal voids in demineralized enamel, to produce net mineral gain. Recently, a range of novel calcium-phosphate-based remineralization delivery systems has been developed for clinical application. These delivery systems include crystalline, unstabilized amorphous, or stabilized amorphous formulations of calcium phosphate. These systems are reviewed, and the technology with the most scientific evidence to support its clinical use is the remineralizing system utilizing casein phosphopeptides to stabilize and deliver bioavailable calcium, phosphate, and fluoride ions. The recent clinical evidence for this technology is presented and the mechanism of action discussed. Biomimetic approaches to stabilization of bioavailable calcium, phosphate, and fluoride ions and the localization of these ions to non-cavitated caries lesions for controlled remineralization show promise for the non-invasive management of dental caries.


Journal Details

This article was published in the following journal.

Name: Journal of dental research
ISSN: 1544-0591


PubMed Articles [10495 Associated PubMed Articles listed on BioPortfolio]

Ultrastructural evaluation of enamel surface morphology after tooth bleaching followed by the application of protective pastes.

The aim of the present in vitro study was to evaluate the morphology of bleached enamel surface followed by the application of different protective pastes. Specimens were prepared from 50 human inciso...

Structural Morphology of Molars in Large Mammalian Herbivores: Enamel Content Varies between Tooth Positions.

The distribution of dental tissues in mammalian herbivores can be very different from taxon to taxon. While grazers tend to have more elaborated and complexly folded enamel ridges, browsers have less ...

Remineralizing Effect of Child Formula Dentifrices on Artificial Enamel Caries Using a pH Cycling Model.

Although fluoridated toothpastes are among the most accessible fluoride sources for caries prevention, their remineralization potential remains questionable. This study sought to compare the effects o...

Enamel Regeneration in Making a Bioengineered Tooth.

Overall enamel is the hard tissue overlying teeth that is vulnerable to caries, congenital defects, and damage due to trauma. Not only is enamel incapable of self-repair in most species, it is also su...

Epigenetic Control of Gene Function in Enamel Development.

Amelogenesis consists of various development phases that are tightly controlled by the exquisitely sequential and reciprocal interactions between tooth epithelium and mesenchyme. Subtle alterations du...

Clinical Trials [1242 Associated Clinical Trials listed on BioPortfolio]

Enamel Remineralization Potential of Dentifrices in Situ

This study will use an oral in situ caries model to study remineralization of enamel due to the action of different combinations of fluoride salts delivered from dentifrices.

Study of Factors of Genetic Susceptibility Associated to Severe Caries Phenotype

Alteration of the post- eruptive enamel microstructure due to a mutation of a gene coding for a matrix protein could increase the susceptibility of the enamel to caries after tooth eruptio...

Development and Validation of a Multi-Mineral Fluoride Mouthrinse

The primary goals of this project are to determine the anticaries benefits of a prototype multi-mineral mouthrinse containing 225 ppm fluoride and 30 ppm of a Ca through the remineralizati...

Study to Investigate the Intial Stages of Enamel Erosion in Vivo

This exploratory study is designed to help develop a clinical model to measure the earlier stages of dietary acid medicated enamel loss. The study will use fluoride as positive control to ...

Analysis of Enamel Wear Against Ceramic Restorations

1. To characterize the microstructure (fracture toughness, particle size of ceramic, and inter-particle spacing) of three ceramic materials 2. To test the hypothesis that lower fra...

Medical and Biotech [MESH] Definitions

Epithelial cells surrounding the dental papilla and differentiated into three layers: the inner enamel epithelium, consisting of ameloblasts which eventually form the enamel, and the enamel pulp and external enamel epithelium, both of which atrophy and disappear before and upon eruption of the tooth, respectively.

An acquired or hereditary condition due to deficiency in the formation of tooth enamel (AMELOGENESIS). It is usually characterized by defective, thin, or malformed DENTAL ENAMEL. Risk factors for enamel hypoplasia include gene mutations, nutritional deficiencies, diseases, and environmental factors.

Therapeutic technique for replacement of minerals in partially decalcified teeth.

The constricted part of the tooth at the junction of the crown and root or roots. It is often referred to as the cementoenamel junction (CEJ), the line at which the cementum covering the root of a tooth and the enamel of the tooth meet. (Jablonski, Dictionary of Dentistry, 1992, p530, p433)

The upper part of the tooth, which joins the lower part of the tooth (TOOTH ROOT) at the cervix (TOOTH CERVIX) at a line called the cementoenamel junction. The entire surface of the crown is covered with enamel which is thicker at the extremity and becomes progressively thinner toward the cervix. (From Jablonski, Dictionary of Dentistry, 1992, p216)


Relevant Topics

Dentistry is the study, management and treatment of diseases and conditions affecting the mouth, jaw, teeth and their supporting tissues (Oxford Medical Dictionary) The work of a dentist ranges from regular patient check-up to orthodontics and surgery....

Public Health
Alternative Medicine Cleft Palate Complementary & Alternative Medicine Congenital Diseases Dentistry Ear Nose & Throat Food Safety Geriatrics Healthcare Hearing Medical Devices MRSA Muscular Dyst...

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...