Notoamide O, a Structurally Unprecedented Prenylated Indole Alkaloid, and Notoamides P-R from a Marine-Derived Fungus, Aspergillus sp.
Summary of "Notoamide O, a Structurally Unprecedented Prenylated Indole Alkaloid, and Notoamides P-R from a Marine-Derived Fungus, Aspergillus sp."
Notoamides O-R were isolated from a marine-derived Aspergillus sp. Notoamide O possesses a novel hemiacetal/hemiaminal ether functionality hitherto unknown among this family of prenylated indole alkaloids. The structure represents an unusual branch point for the oxidative modification of other members in the family of prenylated indole alkaloids in the biogenetic pathway.
Affiliation
Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan, Graduate School of Science, Chiba University, Inage-ku, Chiba 263-8522, Japan, and RIKEN Genomic Sciences Center (GSC), Tsurumi-ku, Yokohama 230-0045, Japan.
Journal Details
This article was published in the following journal.
Name: Journal of natural products
ISSN: 1520-6025
Pages: 1438-40
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20795742
- DOI: http://dx.doi.org/10.1021/np1002498
Medical and Biotech [MESH] Definitions
Alstonia
A plant genus of the family APOCYNACEAE. Members contain echitovenidine, echitamine, venenatine (an indole alkaloid), and anti-inflammatory triterpenoids
Carbolines
A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.
Carbazoles
Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.
Peperomia
A plant genus of the family PIPERACEAE. Members contain prenylated quinones.
Achyrocline
A plant genus of the family ASTERACEAE. Members contain TERPENES and achyrofuran, a prenylated dibenzofuran (BENZOFURANS).
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