Biomaterials based on new polyurethane and hydrolyzed collagen; k-elastin; hyaluronic acid and chondroitin sulfate.
Summary of "Biomaterials based on new polyurethane and hydrolyzed collagen; k-elastin; hyaluronic acid and chondroitin sulfate."
In this paper biomaterials based on various polyurethane formulations have been physical characterized by FT-IR spectroscopy, contact angle measurements, DSC, TG-DTG and SEM methods. It has been established that the transition temperatures of soft and hard segments of polyurethane (glass transition or melting) depend on the blend composition. The melting temperature varies from 54.2 (o)C to 81.9 (o)C for soft segments, and from 220 (o)C to 235 (o)C for hard segments. FT-IR spectrometry allows identifying the functional groups involved in interactions and consequently the changes in polymer chain mobility. From SEM images, is evident that polyurethanic film is porous and spongious. By adding of the others components such as hydrolysed collagen, elastin, chondroitin sulfate or hyaluronic acid, a reduction of porosity of films was obtained.
"Petru Poni" Institute of Macromolecular Chemistry, Department of Physical Chemistry of Polymers, 41A Grigore Ghica Voda Alley, Iasi, Romania.
This article was published in the following journal.
Name: International journal of biological macromolecules
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20800612
- DOI: http://dx.doi.org/10.1016/j.ijbiomac.2010.08.013
Medical and Biotech [MESH] Definitions
Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)
A polymorphonuclear leukocyte-derived serine protease that degrades proteins such as ELASTIN; FIBRONECTIN; LAMININ; VITRONECTIN; and COLLAGEN. It is named for its ability to control myeloid cell growth and differentiation.
A salt-soluble precursor of elastin. Lysyl oxidase is instrumental in converting it to elastin in connective tissue.
Collagen Type V
A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.
Connective Tissue Diseases
A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
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