Daptomycin as successful treatment for a refractory case of prosthetic valve endocarditis because of methicillin-sensitive Staphylococcus aureus.
Summary of "Daptomycin as successful treatment for a refractory case of prosthetic valve endocarditis because of methicillin-sensitive Staphylococcus aureus."
We report on an intravenous drug user who presented with methicillin-sensitive Staphylococcus aureus bacteremia and endocarditis of a prosthetic tricuspid valve, with a 4-cm vegetation refractory to standard antibiotic treatment. The patient responded to intravenous daptomycin therapy clinically and microbiologically, despite an absence of surgical intervention.
Affiliation
Division of Cardiology, United Christian Hospital, Kwun Tong, Hong Kong.
Journal Details
This article was published in the following journal.
Name: Heart & lung : the journal of critical care
ISSN: 1527-3288
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20800283
- DOI: http://dx.doi.org/10.1016/j.hrtlng.2010.06.002
Medical and Biotech [MESH] Definitions
Endocarditis, Bacterial
Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.
Mitral Valve Annuloplasty
A type of heart valve surgery that involves the repair, replacement, or reconstruction of the annulus of the MITRAL VALVE. It includes shortening the circumference of the annulus to improve valve closing capacity and reinforcing the annulus as a step in more complex valve repairs.
Dental Marginal Adaptation
The degree of approximation or fit of filling material or dental prosthetic to the tooth surface. A close marginal adaptation and seal at the interface is important for successful dental restorations.
Cardiac Valve Annuloplasty
A type of heart valve surgery that involves the repair, replacement, or reconstruction of the annuli of HEART VALVES. It includes shortening the circumference of the annulus to improve valve closing capacity and reinforcing the annulus as a step in more complex valve repairs.
Tricuspid Valve Prolapse
Abnormal protrusion of one or more of the leaflets of TRICUSPID VALVE into the RIGHT ATRIUM during SYSTOLE. This allows the backflow of blood into right atrium leading to TRICUSPID VALVE INSUFFICIENCY; SYSTOLIC MURMURS. Its most common cause is not primary valve abnormality but rather the dilation of the RIGHT VENTRICLE and the tricuspid annulus.
PubMed Articles
Extensive, devastating prosthetic aortic valve endocarditis. Case Report.
In this report, we present a case of a 68-year-old male who developed extensive, devastating prosthetic valve endocarditis (PVE) several months following aortic valve replacement with a tissue valve S...
Prosthetic Valve Endocarditis Caused by Staphylococcus Capitis: Report of 4 Cases.
ABSTRACT: Although Staphylococcus capitis is considered to be a rare causative organism for prosthetic valve endocarditis, we report 4 such cases that were encountered at our hospital over the past 2...
Brucella glomerulonephritis and prosthetic valve endocarditis: a case report.
Although brucellosis is an endemic disease in Mediterranean countries, there are few reported cases of Brucella endocarditis and glomerulonephritis. We report a case of Brucella prosthetic mitral valv...
ABSTRACT: BACKGROUND: Emergence of daptomycin-nonsusceptible (DNS) Staphylococcus aureus is a dreadful problem in the treatment of endocarditis. Few current therapeutic agents are effective for treati...
Brucellosis relapse causing prosthetic valve endocarditis and aortic root infective pseudoaneurysm.
We report a previously treated case of brucellosis and aortic root replacement, which became complicated by prosthetic valve endocarditis and a massive aortic root pseudoaneurysm. Preoperative blood a...
Clinical Trials
Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis.
The aim of this study is to determine the safety and efficacy of daptomycin when used as an adjuvant agent to standard care in the treatment of proven native valve Enterococcal endocarditi...
Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus
The purpose of this study is to compare the safety and efficacy of daptomycin, an antibiotic, to standard therapy in subjects who have infective endocarditis or bacteremia due to Staphyloc...
multicenter, randomized, double blind study to describe the safety and efficacy of daptomycin (6 mg/kg q24h) with and without concomitant initial gentamicin combination therapy in the trea...
This is a research study designed to look at the efficacy and safety of daptomycin given at a dose of 6 mg/kg or 8 mg/kg in subjects being treated for prosthetic hip or knee infections cau...
The overall goals of this study are to compare the safety and efficacy of daptomycin monotherapy 10 mg/kg/day and vancomycin monotherapy dosed to achieve vancomycin trough levels of 15 to...
