Cytogenotoxicity in uroepithelial cells of women exposed to mercury in a mining area.
Summary of "Cytogenotoxicity in uroepithelial cells of women exposed to mercury in a mining area."
Objective To investigate biomarkers of cytogenotoxicity in women exposed to mercury in a mining area. Mercury has been associated with cytogenotoxicity in human and animal models but has not been considered carcinogenic in humans, even though genotoxic effects following exposure to inorganic mercury compounds have been observed. Methods A cross-sectional study and micronucleus assay in uroepithelial cells were performed in 104 women (12-84 years of age). First urine void samples were taken to determine creatinine-adjusted mercury levels in urine (HgUCr), to isolate cells and to quantify cytogenetic damage. Results The geometric average level for HgUCr was 4.9 mug/g (range, 0.4-85). In the generalised linear model, after controlling for other co-variables, we observed that for each 10 mug/g increase in HgUCr, the OR of developing a genotoxic effect was 2.37 (95% CI 1.79 to 2.84), while for cytotoxic damage in uroepithelial cells the OR was 1.34 (95% CI 1.10 to 1.79). These results suggest a possible association between cytogenotoxicity and HgUCr. Conclusion Living in a mining area with exposure to inorganic mercury and having higher mercury levels in urine increased the risk of developing uroepithelial cytogenotoxicity.
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This article was published in the following journal.
Name: Occupational and environmental medicine
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20798028
- DOI: http://dx.doi.org/10.1136/oem.2009.047928
Medical and Biotech [MESH] Definitions
Stable mercury atoms that have the same atomic number as the element mercury, but differ in atomic weight. Hg-196, 198-201, and 204 are stable mercury isotopes.
Unstable isotopes of mercury that decay or disintegrate emitting radiation. Hg atoms with atomic weights 185-195, 197, 203, 205, and 206 are radioactive mercury isotopes.
A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
Inorganic compounds that contain mercury as an integral part of the molecule.
Organic mercury compounds in which the mercury is attached to an ethyl group.
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