ScvO2 As a Marker to Define Fluid Responsiveness.

02:09 EST 1st February 2015 | BioPortfolio

Summary of "ScvO2 As a Marker to Define Fluid Responsiveness."

: Definition of the hemodynamic response to volume expansion (VE) could be useful in shocked critically ill patients in absence of cardiac index (CI) measurements. The aim of this study is to evaluate whether central venous oxygen saturation variations (DeltaScvO2 after VE could be an alternative to classify responders (R) and nonresponders (NR) to volume therapy.
: A total of 30 patients requiring VE were included in this prospective cohort study, all equipped with radial arterial line and pulmonary artery catheters. CI, mixed venous oxygen saturation (SvO2) and ScvO2 were measured before and after VE. CI, SvO2, and ScvO2 changes after volume were analyzed using linear regression. Receiver operating characteristics curve analysis was used to test their ability to distinguish R and NR.
: DeltaScvO2 and SvO2 variations after VE (DeltaSvO2) were significantly correlated with CI changes (DeltaCI) after VE (r = 0.67 and r = 0.49, p < 0.001, respectively). A DeltaScvO2 threshold value of 4% allowed the definition of R and NR patients with 86% sensitivity (95%CI; 57-98%) and 81% specificity (95%CI; 54-96%).
: ScvO2 variations after VE was able to categorize VE efficiently and could be suggested as an alternative marker to define fluid responsiveness in absence of invasive CI measurement.


From the Intensive Care Unit (R.G., N.S., J-A.R., K.B.), University Hospital of Geneva, Switzerland; Division of Biostatistics (A.G-A., C.C.), University Hospital of Geneva, Switzerland; and Department of Clinical Research (C.C.), University of Geneva, Sw

Journal Details

This article was published in the following journal.

Name: The Journal of trauma
ISSN: 1529-8809


PubMed Articles [6651 Associated PubMed Articles listed on BioPortfolio]

A 10 second fluid challenge guided by transthoracic echocardiography can predict fluid responsiveness.

The accurate assessment of intravascular volume status for the therapy of severe hypovolemia and shock is difficult and critical to critically ill patients. Noninvasive evaluation of fluid responsiven...

Reliability of Continuous Non-Invasive Assessment of Hemoglobin and Fluid Responsiveness: Impact of Obesity and Abdominal Insufflation Pressures.

During surgery, proper fluid resuscitation and hemostatic control is critical. Pleth variability index (PVI) is advocated as a reliable way of optimizing intraoperative fluid resuscitation. PVI is a m...

Fluid resuscitation based on dynamic predictors of fluid responsiveness: closed loop algorithm versus anesthesiologists.

Fluid choices impact outcome in septic shock.

We discuss the goals of resuscitation, in both the early and the later phases, measures of organ perfusion, fluid responsiveness and the consequences of tissue edema.

Pulse pressure variation is not a valid predictor of fluid responsiveness in patients with elevated left ventricular filling pressure.

The purpose of this study was to test the hypothesis that the predictive ability of pulse pressure variation (PPV) for fluid responsiveness would be altered in patients with elevated left ventricular ...

Clinical Trials [1479 Associated Clinical Trials listed on BioPortfolio]

Fluid Responsiveness Prediction at the Bedside

The purpose of this study is to verify the accuracy and applicability of predictors of fluid administration efficacy in hypotensive critically ill patients.

Validation of the Fluid Responsiveness Index in Critically Ill Patients

Fluid therapy is an important part of the management of patients with hemodynamic instability in the intensive care unit. By increasing cardiac preload, it aims at elevating cardiac output...

Pulse Pressure Variation (PPV) to Predict Fluid Responsiveness During Cardiac Displacement in Patients Undergoing Off-pump Coronary Artery Bypass Surgery (OPCAB)

Pulse pressure variation (PPV) known as a dynamic preload index is increasingly being used for guide of fluid management under various clinical situations. We hypothesized that PPV could p...

C-Reactive Protein as a Predictor for Airway Hyper-Responsiveness

Background: Increased serum high sensitivity C-reactive protein (hs-CRP) has been associated with airway inflammation in asthma and may serve as a surrogate marker for the presence of airw...

Can Capillary Refill Time Variation During Passive Leg Raising Predict Fluid Responsiveness

Fluid responsiveness in a context of circulatory failure can be assessed by different way. Microcirculatory evaluation to assess fluid responsiveness could be interesting, but the availabl...

Medical and Biotech [MESH] Definitions

The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.

Fluid collected from nipple by gentle aspiration. The fluid contains cells and extracellular fluid from the breast ductal epithelium.

Vaccines used in conjunction with diagnostic tests to differentiate vaccinated animals from carrier animals. Marker vaccines can be either a subunit or a gene-deleted vaccine.

Tubes inserted to create communication between a cerebral ventricle and the internal jugular vein. Their emplacement permits draining of cerebrospinal fluid for relief of hydrocephalus or other condition leading to fluid accumulation in the ventricles.

The fluid surrounding the OVUM and GRANULOSA CELLS in the Graafian follicle (OVARIAN FOLLICLE). The follicular fluid contains sex steroids, glycoprotein hormones, plasma proteins, mucopolysaccharides, and enzymes.

Search BioPortfolio:

Relevant Topic

Latest News Clinical Trials Research Drugs Reports Corporate
Pulmonary relating to or associated with the lungs eg Asthma, chronic bronchitis, emphysema, COPD, Cystic Fibrosis, Influenza,  Lung Cancer, Pneumonia, Pulmonary Arterial Hypertension, Sleep Disorders etc Follow and track Lung Cancer News ...