Averting inflammation by targeting the cytokine environment.
Summary of "Averting inflammation by targeting the cytokine environment."
Cytokines are key instigators and regulators of immune responses and therefore hold great potential as targets for new therapeutic strategies. However, the selection of which cytokines to target, and in particular the identification of which cytokines regulate the rate-limiting steps of disease pathways, is crucial to the success of such strategies. Moreover, balancing the need for ablating pathological inflammatory responses and simultaneously maintaining the ability to control infectious agents is a key consideration. Recent advances in our understanding of cytokine networks, as well as technical progress in blocking cytokines in vivo, are likely to be a source for new drugs that can control chronic inflammatory diseases.
Affiliation
Molecular Biomedicine, Institute of Integrative Biology, ETH Zürich, Wagistrasse 27, 8952 Zürich, Switzerland.
Journal Details
This article was published in the following journal.
Name: Nature reviews. Drug discovery
ISSN: 1474-1784
Pages: 703-18
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20811382
- DOI: http://dx.doi.org/10.1038/nrd2805
Medical and Biotech [MESH] Definitions
Cytokine Receptor Gp130
A cytokine receptor that acts through the formation of oligomeric complexes of itself with a variety of CYTOKINE RECEPTORS.
Extraterrestrial Environment
The environment outside the earth or its atmosphere. The environment may refer to a closed cabin (such as a space shuttle or space station) or to space itself, the moon, or other planets.
Interleukin-9
A multifunctional cytokine secreted by primarily by activated TH2 CELLS that may play a role as a regulator of allergic INFLAMMATION. It has been shown to enhance the growth and CELL DIFFERENTIATION of MAST CELLS, and can act on a variety of other immune cells.
Social Adjustment
Adaptation of the person to the social environment. Adjustment may take place by adapting the self to the environment or by changing the environment. (From Campbell, Psychiatric Dictionary, 1996)
Suppressor Of Cytokine Signaling Proteins
A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.
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