A Model for Calcium Permeation into Small Intestine.
Summary of "A Model for Calcium Permeation into Small Intestine."
An in vitro model was used to simulate the intestinal permeation of calcium ions depending on the type of salt (carbonate, fumarate, citrate, or gluconate), its concentration (1.0, 2.5, 5.0, or 10 mM/l), and pH (1.3, 4.2, 6.2, or 7.5). To simulate the conditions for calcium permeation in a patient in a fasting state, the solutions were placed in contact with segments of small intestine of pig: stomach, duodenum, jejunum, and ileum. The percent permeation, its rate, and half-time were measured in each case. In all cases, the maximum permeation was seen at 1 mM concentration, depending on p
H:
100% for carbonate at pH 1.3; 82% for fumarate, pH 6.2; 79.5% for citrate at pH 4.2, and 81% for gluconate at pH 7.4. The maximum rate of permeation (% h(-1)) was also observed at 1 m
M:
2.16 for carbonate at pH 1.3, 0.29 for fumarate at pH 6.2, 0.26 for citrate at pH 4.2, and 0.28 for gluconate at pH 7.4. The shortest half-time permeation (t (1/2), h) for 1 mM solutions depended also on pH (in parentheses): carbonate 0.3 (1.3), fumarate 2.4 (6.2), citrate 2.6 (4.2), and gluconate 2.5 (7.4). The results suggest that calcium carbonate and citrate can be recommended to patients with normal gastric acidity and hyperacidity while fumarate and gluconate to patients with hypoacidity.
Affiliation
Pharmaceutical Research and Production Plant, Biochefa, Kasztanowa 3, 41-205, Sosnowiec, Poland, b.dolinska@biochefa.pl.
Journal Details
This article was published in the following journal.
Name: Biological trace element research
ISSN: 1559-0720
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20809269
- DOI: http://dx.doi.org/10.1007/s12011-010-8827-6
Medical and Biotech [MESH] Definitions
Jejunal Neoplasms
Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).
Duodenal Diseases
Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).
Ileal Neoplasms
Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).
Duodenitis
Inflammation of the DUODENUM section of the small intestine (INTESTINE, SMALL). Erosive duodenitis may cause bleeding in the UPPER GI TRACT and PEPTIC ULCER.
Jejunum
The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.
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